The paper presents data regarding the status of some important bioelements that act as cofactors for different enzymes in rats with induced oxidative stress by the administration of aluminum and cisplatinum. The study was made on thirty-six Wistar albino young rats (three months old) divided randomly in four groups as follows: C-Control, 1 ml of physiologically saline (P.S); E1-administration of 100 mg/kg bw AlCl3; E2-administration of 10 mg/kg bw cisplatinum; E3-administration of 100 mg/kg bw AlCl3 and 10 mg/kg bw cisplatinum. All administrations were via the intraperitoneal route (i.p.), once a week, for a four weeks period. Were measured the oxidative stress enzymes CAT (catalase), SOD (superoxide dismutase), glutathione peroxidase (GPx), Glutathione reductase (GSH-r) and the blood levels of iron, manganese, magnesium, copper, zinc, and selenium. In all experimental groups were observed the significant decrease of CAT, the significant increase of GPx and GSH-r, not significant increase of SOD, not significant fluctuations of manganese and magnesium, a significant decrease of zinc and copper and not significant decrease of selenium. We can conclude that aluminum and cisplatinum can impair the normal status of the main bioelements through induced oxidative stress.
Dialysis represents the separation process of a colloidal dispersion substance from molecular dispersion particles, based on the property of certain membranes to retain only colloidal particles. In veterinary medicine, the most common use for peritoneal dialysis is the therapy of acute kidney injury, although it can be employed for removing dialyzable toxins and treating pancreatitis, electrolyte disorders and acid-base imbalances, refractory congestive heart failure and metabolic congenital disorders. Peritoneal dialysis is contraindicated in patients with peritoneal adhesions, fibrosis or abdominal malignant tumours. The ideal catheter for dialysis allows for an adequate administration and evacuation of the dialysate, it determines minimum subcutaneous losses, it minimizes infection both in the peritoneal cavity and in the subcutaneous tissue. The placement method for peritoneal dialysis catheters depends on the catheter itself, on the patient and on the approximate duration of the dialysis. In cases of extreme emergency, when the peritoneal dialysis should not be used more than 72 hours, the placement of a short-term catheter is justified. The peritoneal dialysis system is placed immediately after the peritoneal dialysis catheter is inserted and attached to a closed collection system, being carefully prepped in place with dry sterile dressings. The ideal peritoneal dialysis solution should achieve the low absorption clearance of osmotic agents, provide missing or insufficient electrolytes and nutrients, correct acid-base imbalances, inhibit growth of microorganisms, and be inert with regard to the peritoneum. When initiating peritoneal dialysis in acute kidney injury, the main goal is not to immediately normalize uraemia. The initial objectives should be to normalize the hemodynamic status of the patient and the acid-base and electrolyte imbalances, as well as to reduce uraemia to a BUN of 60-100 mg/dl and to reach a creatinine of 4.0-6.0 mg/dl in 24-48 hours. Complications of peritoneal dialysis are common, but they can be easily managed if discovered or addressed in due time. The most common complications are: peritoneal catheter obstruction, electrolyte imbalances, hypoalbuminemia and bacterial peritonitis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.