We describe 5 cases of severe necrotizing vasculitis following the RNA-based vaccine for SARS-COV2, including 4 relapsing ANCA vasculitis, 27 days (1-60) after vaccination and 1 patient with quiescent chronic hepatitis B and de novo polyarteritis nodosa (PAN) 21 days after vaccination. Ten other cases were reported to the French national pharmacovigilance database: 6 patients with ANCA-associated vasculitis and 4 patients with PAN (first symptoms 19 days on average after vaccination). Five of these 10 patients developed kidney dysfunction. In conclusion, COVID-19-vaccines can be associated with de novo or recurrent ANCA vasculitis or PAN. Attention should be paid to patients with known ANCA vasculitis or patients with history of hepatitis B infection.
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