Efficient and general procedures for the cross-coupling
of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported.
Fine-tuning of the reaction conditions allows for either site-selective,
double, or alkynylative cross-coupling, therefore providing divergent
and straightforward entries to numerous building blocks such as bromoenamides,
ynamides, ketene N,N-acetals, bromoenol
ethers, ynol ethers, ketene O,O-acetals,
or vinylphosphonates and further expanding the copper catalysis toolbox
with useful and versatile processes.
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