Recebido em 29/10/96; aceito em 17/4/97 CHEMICAL MODIFICATIONS OF (+)-ALLO-AROMADENDRANE-10β,14-DIOL ISOLATED FROM DUGUETIA GLABRIUSCULA R. E. FRIES (R. E. FRIES) (ANNONACEAE) AND BIO-LOGICAL EVALUATION OF SOME OBTAINED DERIVATIVES. The sesquiterpene (+)-alloaromadendrane-10β-14-diol 1 was the lead compound to the preparation of several derivatives in order to test their biological activity against A. salina, C. sphaerospermum, E. coli and S. aureus. In this way the monoalcohols (+)-viridiflorol 4, 9 and 11 were synthesized from 1 together with the acetal 6, the ketal 7, and the ketone 8. The oxirane 3 and nitrile 5 were also prepared using as an intermediate the tosylate derivative 2.
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