Background: Mass spectrometry is a key technique in proteomics and can be used to analyze complex samples quickly. One key problem with the mass spectrometric analysis of peptides and proteins, however, is the fact that absolute quantification is severely hampered by the unclear relationship between the observed peak intensity and the peptide concentration in the sample. While there are numerous approaches to circumvent this problem experimentally (e.g. labeling techniques), reliable prediction of the peak intensities from peptide sequences could provide a peptide-specific correction factor. Thus, it would be a valuable tool towards label-free absolute quantification.
Abstract. Within this paper we present the extension of two neural network paradigms for clustering tasks. The Self Organizing feature Maps (SOM) are extended to the Multi SOM approach, and the Neural Gas is extended to a Multi Neural Gas. Some common cluster analysis coefficients (Silhouette Coefficient, Gap Statistics, Calinski-Harabasz Coefficient) have been adapted for the new paradigms. Both new neural clustering methods are described and evaluated briefly using exemplary data sets.
Within this paper we present the extension of two neural network paradigms for clustering tasks. The Self Organizing feature Maps (SOM) are extended to the Multi SOM approach, and the Neural Gas is extended to a Multi Neural Gas. Some common cluster analysis coefficients (Silhouette Coefficient, Gap Statistics, Calinski-Harabasz Coefficient) have been adapted for the new paradigms. Both new neural clustering methods are described and evaluated briefly using exemplary data sets.0-7803-9490
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