This article presents the design of Didactic Strategy Modeling Language (DSML), according to the principles of Physics of Notations (PoN). DSML is a visual and activity-oriented language for learning design whose main characteristic lies in the representation of the different activities according to the nature of the task. The language requirements are established based on the exploration of strengths and weaknesses of existing Educational Modeling Languages (EML) proposals. Once the language is designed, a blind interpretation study is conducted to validate the semantic transparency of the learning activity iconography. The results of the study allow to refine icons. Also, an authoring tool for DSML is presented, which is integrated to an LMS. A Model Driven course is designed as a DSML pre-validation.
<p><strong><span style="font-family: Arial; font-size: small;">Objective. </span></strong><span style="font-family: Arial;">To determine the presence of NoVs as a possible causal zoonotic agent of acute diarrhea in pigs and humans. <strong>Materials and methods.</strong> We collected a total of 77 samples from diarrheal children under 5 years and pigs under 2 months from La Chamba town in Tolima, Colombia. These samples were transported to the Laboratory of Virology of the Pontificia Universidad Javeriana in Bogotá, and extraction with Trizol-reagent was done following the manufacturer's instructions. After obtaining the RNA, the next step was to perform RT-PCR for obtaining the expected amplification product of 213- bp NoVs. Finally, the positive samples obtained in the RT-PCR were sequenced and analyzed by bioinformatics methods. <strong>Results.</strong> Six positive diarrheic samples from children and a positive diarrheic sample from pigs were detected by a band of 231 bp. Five of the six positive samples in children and the positive pig sample were sequenced and analyzed. <strong>Conclusion.</strong> Given the close genetic relationship between pig and human sequences, this could be an indication of the potential existence of a common animal acting as a reservoir for human or other animal strains.</span></p> <p><span style="color: black; font-family: Arial; font-size: small;"> </span></p> <p><strong><span style="font-family: Arial; font-size: small;">Key words: </span></strong><span style="font-family: Arial;">Human Norovirus, domestic pigs, diarrhea, zoonotic transmission, reservoirs</span></p>
El volumen Aesthetic Reason and Imaginative Freedom: Friederich Schiller and Philosophy continúa un esfuerzo que se viene gestando desde hace más de quince años en el ámbito de la investigación filosófica: restituir la figura de Friedrich Schiller como filósofo.
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