<b><i>Objective:</i></b> Malposition of peripherally inserted central catheters (PICCs) is common. Recommendations for PICC insertion depths are scarce and comprise complex equations. This study aimed to develop diagrams and tables for the recommendation of PICC insertion depths in neonates based on anthropometric parameters. <b><i>Study Design:</i></b> In this retrospective single-center study, the individual optimal PICC insertion depths were correlated with body weight, length, and head circumference. Using linear regression analysis, line charts and tables for the recommendation of PICC insertion depth were generated and compared with previously published recommendations. <b><i>Result:</i></b> PICC insertion depths of 204 infants (gestational age at PICC installation: 24.0–44.9 weeks) with 131 (64%) PICC in the upper extremities and 73 (36%) in the lower extremities were analyzed. Linear logistic regression models revealed <i>R</i><sup>2</sup> values between 0.387 and 0.884. <b><i>Conclusion:</i></b> The charts and table developed in this study enable a fast and accurate determination of recommended PICC insertion depths in neonates.
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