Various factors correlated to PFO that tend to increase its causal relationship with cryptogenic ischemic stroke include: young age, valsalva maneuver (VM), recent prolonged immobility, concomitant DVT in legs or pelvis, presence of atrial septal aneurysm (ASA), history of migraine with aura, and neuroimaging demonstrating solitary cortical or bilateral embolic pattern. 3 Few of these factors have been discussed in the following section.
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