No abstract

In treatment-naïve patients with T2D, dapagliflozin plus metformin was generally well tolerated and effective in reducing HbA1c, FPG and weight. Dapagliflozin-induced glucosuria led to an increase in events suggestive of urinary tract and genital infections.

No abstract

ZOSTAVAX and influenza vaccine given concomitantly are generally well tolerated in adults aged 50 and older. Ab responses were similar whether ZOSTAVAX and influenza vaccine were given concomitantly or sequentially.

The drive to further increase gas turbine thermal efficiency and specific power output continue to elevate core temperatures well beyond the natural capabilities of the metals employed in their manufacture necessitating increasingly complex cooling systems. One such cooling mechanism is the double-wall, effusion-cooled system which combines in a very compact format, many cooling aspects already implemented in gas turbine cooling. To-date, thermomechanical stresses have provided one of the more significant challenges in the implementation of these systems and needs to be considered — alongside aerothermal performance — at the initial stages of design. This paper presents a novel computational method that has been developed to allow an integrated assessment of both the aerothermal and thermomechanical performance of double-wall cooling geometries. A decoupled conjugate method was developed in which internal cooling performance was ascertained via a conjugate CFD model in which the mainstream flow was not simulated. Instead, external film cooling performance was assessed via a superposition method that was developed and applied to a two-dimensionally varying correlation allowing streamwise film development to be modelled. Results of both the internal and external cooling simulations were then utilised in a conduction model to develop a complete thermal assessment of the geometry. The calculated temperature distribution was used in a thermomechanical FEA analysis permitting an insight into the stress field developed within the double-wall geometry under thermal load. The developed method was demonstrated in the assessment of seven circular pedestal, double-wall geometries in which a range of geometric parameters were investigated. The results provide an insight into the effect of varying these parameters on both the aerothermal performance of the selected geometries, along with the effect on the thermomechanical stress field developed.