Traumatic brain injury (TBI) is a leading cause of death in the United States, and represents 2.5 million Emergency Department attendances, admissions into hospital, and deaths. A range of temperature modulating devices have been used to proactively cool TBI patients; however, there are currently no uniform targeted temperature management (TTM) guidelines in this patient population. Esophageal temperature management (ETM) is a relatively new TTM modality and the purpose of this study is to determine whether ETM is effective in controlling core temperature in TBI cases. This prospective interventional trial was a single-site study that enrolled 12 patients who received a TTM protocol using ETM. Eleven out of 12 patients reached target temperature during the first 10 hours of treatment. A total of 480 temperature measurements were recorded; 85% of the total measurements were within-1°C of target temperature (408 measurements) and 75% were within-0.5°C of target temperature (360 measurements). The average time to target was 5.83-5.01 hours (range 1-20), with an average cooling rate of 0.58°C/h (range 0.15-1.5°C/h). This prospective interventional trial supports that ETM is a feasible TTM modality for severe TBI cases. The esophageal heat transfer device used in this study demonstrated comparable or superior performance to other commercially available TTM modalities, and the low adverse event rate may offer advantages over more invasive methods with reported higher complication rates.

This paper discusses the methodology for the development of a strategic planning tool, and particularly the architectural solution to be adopted, within an integrated ICT solution for the improvement of planning and scheduling systems for the manufacturing of small production lots of complex products. After the analysis of different possible architectural solutions, the paper proposes a hybrid solution that combines existing solvers with the multi-agent system principles. The proposed approach introduces several benefits, namely in terms of flexibility, robustness, and achievement of exploratory alternative solutions, playing interactive what-if simulation supporting decision-makers to take strategic decisions.

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The paper describes intelligent system “Smart Factory” which is designed to increase factory productivity and efficiency of resources utilization in real time (including equipment, manpower, materials, etc.). The objectives and key areas of application are considered and it is shown that system provides flexible event-driven reaction on changes in factory environment, resource allocation, scheduling, optimization and controlling in real time. The developed method of adaptive resource scheduling, main functionality of system and examples of screens are discussed. The results of implementation and measured benefits for Izhevsk Axion Holding are presented.

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ÃÅÌÎÄÈÍÀ̲×ÍÈÉ ÌÎͲÒÎÐÈÍà  ÏÐÀÊÒÈÖ² ²ÍÒÅÍÑÈÂÍί ÒÅÐÀϲ¯ ÊÐÈÒÈ×ÍÈÕ ÑÒÀͲÂРезюме. У статті наведено огляд сучасних методів гемо-динамічного моніторингу у відділенні інтенсивної терапії. HEMODYNAMIC MONITORING IN PRACTICE OF INTENSIVE CARE UNITSummary. The article prese nts an overview of modern methods of hemodynamic monitoring in the intensive care unit.