Dedicated to Professor Armand Lattes on 50th anniversary of his educational and scientific activity Abstract A new and efficient high yielding synthesis of N-substituted 3-cyanopyridin-2-ones has been developed. The reaction of ylidencyanoacetic acid ethyl esters and dimethylformamide dimethyl acetal has been investigated. Intermediate dimethylamino derivatives so formed were treated with various primary amines in xylene. The targeted 3-cyanopyridin-2-ones were obtained in good yields.
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