Objectives: The aim of this study was to evaluate the hepatoprotective activity of resveratrol in patients with morphofunctional liver disorders due to mechanical jaundice. Methods: The controlled mechanical jaundice was simulated on the rats under anesthesia by drainage of the choledochus and its plugging. In the control group decompression of the choledochus was performed on the 3rd day and intravenous infusion of 0,9% sodium chloride solution was administrated for 12 days. In the experimental group after billiar decompression, resveratrol was administered intravenously at a dose of 20 mg/kg. The following were studied: level of malondialdehyde, catalase, bilirubin, alanine aminotransferase (ALAT), aspartate aminotransferase; liver histology was performed. Results: Catalase was 3.9 times reliably increased, and the activity of malonic dialdehyde and ALAT was 2.0 and 3.6 times reliably decreased in experimental group compared to the control group. Microscopic shows edema and destruction of the liver were reduced, the architectonic of the liver lobules was recovered. Conclusion: Application of resveratrol in mechanical jaundice decreased the processes of free-radical oxidation and level of the liver cells cytolysis markers which morphologically was shown by edema reduction, restoration of the liver lobules structure.
Ïå÷åíü / LiverЦель. Оценка эффективности отрицательных аэроионов в устранении печеночной дисфункции при механической желтухе. Материал и методы. Проведены 2 серии экспериментов на 30 крысах. В 1-й (контрольной) серии моделировали механическую желтуху с последующей декомпрессией общего желчного протока и введением 0,9% раствора хлорида натрия в объеме 40 мл/кг. Во 2-й (опытной) серии воздействовали отрицательными аэроионами (3 млн частиц в 1 см 3 с экспозицией 60 мин 1 раз в сутки на протяжении 12 дней). Изучали уровень билирубина, малонового диальдегида, активность АлАТ и АсАТ, щелочной фосфатазы, каталазы. Результаты. Применение отрицательных аэроионов при механической желтухе способствовало более существенной коррекции показателей функциональной активности печени. Концентрация общего и прямого билирубина уменьшалась до 84,4 ± 7,6 и 42,1 ± 5,4 мкмоль/л, что на 25 и 56% меньше, чем в контрольной серии. Меньше показателей контрольной серии была активность АсАТ и АлАТ, щелочной фосфатазы, концентрация малонового диальдегида (на 17, 22, 18, 47%) и в 3,6 раза больше -активность каталазы. Заключение. Применение отрицательных аэроионов при механической желтухе стимулирует выработку собственных антиоксидантных ферментов, защищающих гепатоциты от свободнорадикального повреждения.
Pulmonary paragonimiasis is a serious parasitic disease caused by the lung fluke larvae. In Russia, the partite is found in the south of the Far East. This article presents a rare clinical case of pulmonary paragonimiasis, which clinically and radiographically mimics the pulmonary tuberculoma. In 2012, the patient served in the Primorsky Krai (one of the natural paragonimiasis foci). In 2016, changes in the right lung were detected. In 2020, the patient underwent a lobectomy of the right lung. A thorough histopathological examination of the surgical material made it possible to reveal a disease, prescribe antiparasitic treatment and help the patient recover from the disease.
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