During activity-dependent potentiation (ADP) motor unit firing rates (MUFRs) are lower, however, the mechanism for this response is not known. During increasing torque isometric contractions at low contraction intensities, MUFR trajectories initially accelerate and saturate demonstrating a non-linear response due to the activation of persistent inward currents (PICs) at the motoneuron. The purpose was to assess whether PICs are a factor in the reduction of MUFRs during ADP. To assess this, MUFR trajectories were fit with competing functions of linear regression and a rising exponential (i.e., acceleration and saturation). Using fine-wire electrodes, discrete MU potential trains were recorded in the tibialis anterior during slowly increasing dorsiflexion contractions to 10% of maximal voluntary contraction following both voluntary (post-activation potentiation; PAP) and evoked (post-tetanic potentiation; PTP) contractions. In 8 participants, 25 MUs were recorded across both ADP conditions and compared to the control with no ADP effect. During PAP and PTP, the average MUFRs were 16.4% and 9.2% lower (both P≤ 0.001), respectively. More MUFR trajectories were better fit to the rising exponential during control (16/25) compared to PAP (4/25, P<0.001) and PTP (8/25, P=0.03). The MU samples that had a rising exponential MUFR trajectory during PAP and PTP displayed an ~11% lower initial acceleration compared to control (P<0.05). Thus, synaptic amplification and MUFR saturation due to PIC properties are attenuated during ADP regardless of the type of conditioning contraction. This response may contribute to lower MUFRs and likely occurred because synaptic input is reduced when contractile function is enhanced.

The triceps surae (TS) length–tension relationship can be altered by changing the knee joint position, ankle joint position or both. However, studies exploring the effect of muscle length on neuromuscular properties have focused only on knee joint position changes affecting two of the three muscle components of the TS. Thus, the purpose of this study is to compare the neuromuscular properties of the three TS muscles during plantar flexion contractions at two ankle joint positions, 20° dorsiflexed (DF) and 20° plantar flexed (PF). Maximal isometric voluntary strength (MVC), voluntary activation, and evoked contractile properties of the ankle plantar flexors were compared between both ankle joint positions. Additionally, soleus, medial (MG), and lateral (LG) gastrocnemii motor unit discharge rates (MUDRs) were sampled during plantar flexion contractions at 25%, 50%, 75%, and 100% MVC using indwelling tungsten electrodes. MVC and peak twitch torque were lower by ~61% and 70%, respectively, whereas the maximal rate of torque relaxation was 39% faster in the PF compared with the DF position. Voluntary activation (~95%) was unaffected by changes in ankle joint position. LG MUDRs showed no differences between ankle joint positions, regardless of contraction intensity. Submaximal MG and soleus MUDRs showed no differences between the two ankle joint positions, however both muscles had 9% and 20% higher MUDRs in the DF position, respectively. These results provide further evidence for the differential activation among the three components of the TS with the greatest increases in soleus MUDRs compared with the gastrocnemii when the muscles are lengthened.

No abstract

The acute phase of COVID‐19 has been well studied, however with increasing post‐acute COVID‐19 syndrome, much is unknown about its long‐term effects. A common symptom in both the acute and post‐acute phases has been fatigue, assessed predominantly qualitatively. Here we present a case study objectively assessing neuromuscular fatiguability in a young male (27 year, 1.85 m, 78 kg) who continues to experience COVID‐19 related fatigue and cognitive dysfunction, including other symptoms, 12+ months post‐infection. Prior to infection, he was part of a neuromuscular study forming the basis of our pre‐COVID‐19 results. The study was repeated 12 months post‐COVID‐19 infection. Muscle strength, endurance, torque steadiness, voluntary activation, twitch properties, electromyography, and compound muscle action potential were obtained and compared pre‐ and post‐COVID‐19. All measurements were done using a dorsiflexion dynamometer in which the participant also was asked to produce a one‐minute fatiguing maximal voluntary contraction. Muscle strength, voluntary activation, and fatigability (slope of torque) showed no meaningful differences, suggesting intrinsic neuromuscular properties are not affected. However, torque steadiness was impaired three‐fold in the post‐ compared with pre‐COVID‐19 test. The participant also reported a higher level of perceived exertion subjectively and a continued complaint of fatigue. These findings indicate that muscle fatiguability in post‐acute COVID‐19 syndrome may not be a limitation of the muscle and its activation, but a perceptual disconnect caused by cognitive impairments relating to physical efforts. This case report suggests the potential value of larger studies designed to assess these features in post‐acute COVID‐19 syndrome.

The purpose was to investigate whether post-activation potentiation (PAP) mitigates power (i.e., torque x angular velocity) loss during dynamic fatiguing contractions and subsequent recovery by enhancing either muscle torque or angular velocity in human plantar flexors. In 12 participants, electrically stimulated (1, 10 and 50 Hz) dynamic contractions were done during a voluntary isotonic fatiguing protocol (20 and 50% voluntary decreases) until a 75% loss in voluntary peak power, and throughout 30 minutes of recovery. At the initial portion of fatigue (20% decrease), power responses of evoked low frequencies (1 and 10 Hz) were enhanced due to PAP (156 and 137%, respectively, P<0.001), while voluntary maximal efforts were depressed due to fatiguing mechanisms. Following the fatiguing task, prolonged low-frequency force depression (PLFFD) was evident by reduced 10:50 Hz peak power ratios (21 - 24%) from 3-min onwards during the 30-min recovery (P<0.005). Inducing PAP with maximal voluntary contractions during PLFFD enhanced the peak power responses of low frequencies (1 and 10 Hz) by 128 - 160 %, P<0.01. This PAP response mitigated the effects of PLFFD as the 1:50 (P<0.05) and 10:50 (P>0.4) Hz peak power ratios were greater or not different from the pre-fatigue values. Additionally, PAP enhanced peak torque more than peak angular velocity during both baseline and fatigue measurements (P<0.03). These results indicate that PAP can ameliorate PLFFD acutely when evaluated during concentric isotonic contractions and that peak torque is enhanced to a greater degree compared to peak angular velocity at baseline and in a fatigued state.