We study the gravitational wave (GW) signature of first-order chiral phase transitions (χPTs) in strongly interacting hidden or dark sectors. We do so using several effective models in order to reliably capture the relevant non-perturbative dynamics. This approach allows us to explicitly calculate key quantities characterizing the χPT without having to resort to rough estimates. Most importantly, we find that the transition's inverse duration β normalized to the Hubble parameter H is at least two orders of magnitude larger than typically assumed in comparable scenarios, namely, β/H O(10 4 ). The obtained GW spectra then suggest that signals from hidden χPTs occurring at around 100 MeV might be in reach of LISA, while DECIGO and BBO may detect a stochastic GW background associated with transitions between roughly 1 GeV and 10 TeV. Signatures of transitions at higher temperatures are found to be outside the range of any currently proposed experiment. Even though predictions from different effective models are qualitatively similar, we find that they may vary considerably from a quantitative point of view, which highlights the need for true first-principle calculations such as lattice simulations. CONTENTS

We investigate the relation between the physical pion pole and screening masses and the mesonic fluctuation scale in low-energy QCD, which relates to the curvature of the mesonic effective potential. This relation is important for the correct relative weight of quantum, thermal and density fluctuations. Hence, it governs the location of phase boundaries as well as the phase structure of QCD. The identification of the correct physics scales is also primarily important for the correct adjustment of the parameters of effective models for low-energy QCD. It is shown that subject to an appropriate definition of the latter, all these scales agree at vanishing temperature, while they deviate from each other at finite temperature.

Within a recently proposed classically conformal model, in which the generation of neutrino masses is linked to spontaneous scale symmetry breaking, we investigate the associated phase transition and find it to be of strong first order with a substantial amount of supercooling. Carefully taking into account the vacuum energy of the meta-stable minimum, we demonstrate that a significant fraction of the model's parameter space can be excluded simply because the phase transition cannot complete. We argue this to be a powerful consistency check applicable to general theories based on classical scale invariance. Finally, we show that all remaining parameter points predict a sizable gravitational wave signal, so that the model can be fully tested by future gravitational wave observatories. In particular, most of the parameter space can already be probed by the upcoming LIGO science run starting in early 2019.

In this work we find the minimal extension of the Standard Model's Higgs sector which can lead to a light Higgs boson via radiative symmetry breaking and is consistent with the phenomenological requirements for a low-energy realization of a conformal theory. The model which turns out to be stable under renormalization group translations is an extension of the Standard Model by two scalar fields, one of which acquires a finite vacuum expectation value and therefore mixes into the physical Higgs. We find that the minimal model predicts a sizable amount of mixing which makes it testable at a collider. In addition to the physical Higgs, the theory's scalar spectrum contains one light and one heavy boson. The heavy scalar's properties render it a potential dark matter candidate.

It was recently proposed that the electroweak hierarchy problem is absent if the generation of the Higgs potential stems exclusively from quantum effects of heavy right-handed neutrinos which can also generate active neutrino masses via the type-I seesaw mechanism. Hence, in this framework dubbed the "neutrino option", the tree-level scalar potential is assumed to vanish at high energies. Such a scenario therefore lends itself particularly well to be embedded in a classically scale-invariant theory. In this paper we perform a survey of models featuring conformal symmetry at the high scale. We find that the minimal framework compatible with the "neutrino option" requires the Standard Model to be extended by two real scalar singlet fields in addition to right-handed neutrinos. The spontaneous breaking of scale invariance, which induces the dynamical generation of Majorana masses for the right-handed neutrinos, is triggered by renormalization group effects. We identify the parameter space of the model for which a phenomenologically viable Higgs potential and neutrino masses are generated, and for which all coupling constants remain in the perturbative regime up to the Planck scale.

Left-right symmetry at high energy scales is a well-motivated extension of the Standard Model. In this paper we consider a typical minimal scenario in which it gets spontaneously broken by scalar triplets. Such a realization has been scrutinized over the past few decades chiefly in the context of collider studies. In this work we take a complementary approach and investigate whether the model can be probed via the search for a stochastic gravitational wave background induced by the phase transition in which SU (3) C × SU (2) L × SU (2) R × U (1) B−L is broken down to the Standard Model gauge symmetry group. A prerequisite for gravitational wave production in this context is a first-order phase transition, the occurrence of which we find in a significant portion of the parameter space. Although the produced gravitational waves are typically too weak for a discovery at any current or future detector, upon investigating correlations between all relevant terms in the scalar potential, we have identified values of parameters leading to observable signals. This indicates that, given a certain moderate fine-tuning, the minimal left-right symmetric model with scalar triplets features another powerful probe which can lead to either novel constraints or remarkable discoveries in the near future. Let us note that some of our results, such as the full set of thermal masses, have to the best of our knowledge not been presented before and might be useful for future studies, in particular in the context of electroweak baryogenesis.

The type-I seesaw represents one of the most popular extensions of the Standard Model. Previous studies of this model have mostly focused on its ability to explain neutrino oscillations as well as on the generation of the baryon asymmetry via leptogenesis. Recently, it has been pointed out that the type-I seesaw can also account for the origin of the electroweak scale due to heavy-neutrino threshold corrections to the Higgs potential. In this paper, we show for the first time that all of these features of the type-I seesaw are compatible with each other. Integrating out a set of heavy Majorana neutrinos results in small masses for the Standard Model neutrinos; baryogenesis is accomplished by resonant leptogenesis; and the Higgs mass is entirely induced by heavy-neutrino one-loop diagrams, provided that the tree-level Higgs potential satisfies scale-invariant boundary conditions in the ultraviolet. The viable parameter space is characterized by a heavy-neutrino mass scale roughly in the range 10 6.5···7.0 GeV and a mass splitting among the nearly degenerate heavy-neutrino states up to a few TeV. Our findings have interesting implications for high-energy flavor models and low-energy neutrino observables. We conclude that the type-I seesaw sector might be the root cause behind the masses and cosmological abundances of all known particles. This statement might even extend to dark matter in the presence of a keV-scale sterile neutrino.

Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and transcriptomic-based diagnostics. The relevance of proteomics for disease classifications remains to be established in clinically heterogeneous cancer entities such as chronic lymphocytic leukemia (CLL). Here, we characterize the proteome and transcriptome alongside genetic and ex-vivo drug response profiling in a clinically annotated CLL discovery cohort (n = 68). Unsupervised clustering of the proteome data reveals six subgroups. Five of these proteomic groups are associated with genetic features, while one group is only detectable at the proteome level. This new group is characterized by accelerated disease progression, high spliceosomal protein abundances associated with aberrant splicing, and low B cell receptor signaling protein abundances (ASB-CLL). Classifiers developed to identify ASB-CLL based on its characteristic proteome or splicing signature in two independent cohorts (n = 165, n = 169) confirm that ASB-CLL comprises about 20% of CLL patients. The inferior overall survival in ASB-CLL is also independent of both TP53- and IGHV mutation status. Our multi-omics analysis refines the classification of CLL and highlights the potential of proteomics to improve cancer patient stratification beyond genetic and transcriptomic profiling.