We propose a two-component reaction-transport model for the migration-proliferation dichotomy in the spreading of tumor cells. By using a continuous time random walk (CTRW) we formulate a system of the balance equations for the cancer cells of two phenotypes with random switching between cell proliferation and migration. The transport process is formulated in terms of the CTRW with an arbitrary waiting time distribution law. Proliferation is modeled by a standard logistic growth. We apply hyperbolic scaling and Hamilton-Jacobi formalism to determine the overall rate of tumor cell invasion. In particular, we take into account both normal diffusion and anomalous transport (subdiffusion) in order to show that the standard diffusion approximation for migration leads to overestimation of the overall cancer spreading rate.

PACS 05.40.-a -Fluctuation phenomena, random processes, noise, and Brownian motion PACS 05.45.-a -Nonlinear dynamics and chaos PACS 42.25.Dd -Wave propagation in random media Abstract -Localization-delocalization transition in a discrete Anderson nonlinear Schrödinger equation with disorder is shown to be a critical phenomenon − similar to a percolation transition on a disordered lattice, with the nonlinearity parameter thought as the control parameter. In vicinity of the critical point the spreading of the wave field is subdiffusive in the limit t → +∞. The second moment grows with time as a powerlaw ∝ t α , with α exactly 1/3. This critical spreading finds its significance in some connection with the general problem of transport along separatrices of dynamical systems with many degrees of freedom and is mathematically related with a description in terms fractional derivative equations. Above the delocalization point, with the criticality effects stepping aside, we find that the transport is subdiffusive with α = 2/5 consistently with the results from previous investigations. A threshold for unlimited spreading is calculated exactly by mapping the transport problem on a Cayley tree.

We study specific properties of particles transport by exploring an exact solvable model, a so-called comb structure, where diffusive transport of particles leads to subdiffusion. A performance of the Lévy-like process enriches this transport phenomenon. It is shown that an inhomogeneous convection flow is a mechanism for the realization of the Lévy-like process. It leads to superdiffusion of particles on the comb structure. This superdiffusion is an enhanced one with an arbitrary large transport exponent, but all moments are finite. A frontier case of superdiffusion, where the transport exponent approaches infinity, is studied. The log-normal distribution with the exponentially fast superdiffusion is obtained for this case.

We suggest a modification of a comb model to describe anomalous transport in spiny dendrites. Geometry of the comb structure consisting of a one-dimensional backbone and lateral branches makes it possible to describe anomalous diffusion, where dynamics inside fingers corresponds to spines, while the backbone describes diffusion along dendrites. The presented analysis establishes that the fractional dynamics in spiny dendrites is controlled by fractal geometry of the comb structure and fractional kinetics inside the spines. Our results show that the transport along spiny dendrites is subdiffusive and depends on the density of spines in agreement with recent experiments.Comment: Accepted for publication in Chaos, Solitons and Fractal

We study the phenomena of Anderson localization in the presence of nonlinear interaction on a lattice. A class of nonlinear Schrödinger models with arbitrary power nonlinearity is analyzed. We conceive the various regimes of behavior, depending on the topology of resonance-overlap in phase space, ranging from a fully developed chaos involving Lévy flights to pseudochaotic dynamics at the onset of delocalization. It is demonstrated that the quadratic nonlinearity plays a dynamically very distinguished role in that it is the only type of power nonlinearity permitting an abrupt localizationdelocalization transition with unlimited spreading already at the delocalization border. We describe this localization-delocalization transition as a percolation transition on the infinite Cayley tree (Bethe lattice). It is found in vicinity of the criticality that the spreading of the wave field is subdiffusive in the limit t → +∞. The second moment of the associated probability distribution grows with time as a powerlaw ∝ t α , with the exponent α = 1/3 exactly. Also we find for superquadratic nonlinearity that the analog pseudochaotic regime at the edge of chaos is self-controlling in that it has feedback on the topology of the structure on which the transport processes concentrate. Then the system automatically (without tuning of parameters) develops its percolation point. We classify this type of behavior in terms of self-organized criticality (SOC) dynamics in Hilbert space. For subquadratic nonlinearities, the behavior is shown to be sensitive to details of definition of the nonlinear term. A transport model is proposed based on modified nonlinearity, using the idea of "stripes" propagating the wave process to large distances. Theoretical investigations, presented here, are the basis for consistency analysis of the different localization-delocalization patterns in systems with many coupled degrees of freedom in association with the asymptotic properties of the transport.