Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.

We present a new algorithm for video coding, learned end-to-end for the low-latency mode. In this setting, our approach outperforms all existing video codecs across nearly the entire bitrate range. To our knowledge, this is the first ML-based method to do so.We evaluate our approach on standard video compression test sets of varying resolutions, and benchmark against all mainstream commercial codecs, in the low-latency mode. On standard-definition videos, relative to our algorithm, HEVC/H.265, AVC/H.264 and VP9 typically produce codes up to 60% larger. On high-definition 1080p videos, H.265 and VP9 typically produce codes up to 20% larger, and H.264 up to 35% larger. Furthermore, our approach does not suffer from blocking artifacts and pixelation, and thus produces videos that are more visually pleasing.We propose two main contributions. The first is a novel architecture for video compression, which (1) generalizes motion estimation to perform any learned compensation beyond simple translations, (2) rather than strictly relying on previously transmitted reference frames, maintains a state of arbitrary information learned by the model, and (3) enables jointly compressing all transmitted signals (such as optical flow and residual).Secondly, we present a framework for ML-based spatial rate control -a mechanism for assigning variable bitrates across space for each frame. This is a critical component for video coding, which to our knowledge had not been developed within a machine learning setting.

A mathematical model and a possible neural mechanism are proposed to account for how fixational drift motion in the retina confers a benefit for the discrimination of high-acuity targets. We show that by simultaneously estimating object shape and eye motion, neurons in visual cortex can compute a higher quality representation of an object by averaging out non-uniformities in the retinal sampling lattice. The model proposes that this is accomplished by two separate populations of cortical neurons-one providing a representation of object shape and another representing eye position or motion-which are coupled through specific multiplicative connections. Combined with recent experimental findings, our model suggests that the visual system may utilize principles not unlike those used in computational imaging for achieving "super-resolution" via camera motion.

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