It has long been known that spermatozoa are antigenic and possess a high degree of immunological specificity ( 1-5). Strong antigenicity was also reported for seminal plasma of man (4-6 ) and several animal species (3 3. 7 ) . Both for spermatozoa and for seminal plasma evidence was obtained that more than one antigenic entity is involved. That spermatozoa and seminal plasma have in comnion powerful and seemingly preponderant antigens has recently been established both for man(4) and guinea pig(:). In man. a t least. indications are that the common antigens do not have their origin in the testes. but in the adnesal glands of the male genital tract. The antigenic material, however. is so firmly adherent to spermatozoa. that it has hitherto been impossible to separate it from these cells by physical means. Further stud!. of the immunological relationship between spermatozoa and seminal plasma seemed to be indicated. with emphasis on the search for the site of production of these antigens.Mcthods. Dutch belted rabbits purchased from Rockland Farms served as semen donors. Semen wa5 obtained by means of the artificial vagina. first developed by llacirone and M-alton(8) and introduced in this country 11~.
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