Asymmetric Synthesis of Spiropyrazolones by Sequential Organo-and SilverCatalysis. -An asymmetric Michael addition and a formal Conia-ene reaction give rise to a stereoselective one-pot synthesis of spiropyrazolones. Depending on the nitroalkene, the 5-exo-dig-cyclization is achieved by silver-catalyzed alkyne activation or by oxidation of the intermediate enolate. This method overcomes some limitations of established spiropyrazolone syntheses. -(HACK, D.; DUERR, A. B.; DECKERS, K.; CHAUHAN, P.; SELING, N.; RUEBENACH, L.; MERTENS, L.; RAABE, G.; SCHOENEBECK*, F.; ENDERS, D.; Angew.
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