This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research Tetrabutylammonium Triphenyldifluorosilicate (TBAT)
Tin(II) chloride dihydrate-mediated deacetalisationbicyclisation procedures for the construction of novel polycyclic heterocycles from amides possessing a pendant acetal group are reported. Optimisation and scoping studies are described; using this methodology, a range of known, and novel, ring-fused heterocyclic systems have been prepared, some in enantiomerically pure form.
The procedure allows a practical access to heterocycles including complex structures via amides possessing a pendant acetal group. -(CAYLEY, A. N.; GALLAGHER, K. A.; MENARD-MOYON, C.; SCHMIDT, J. P.; DIORAZIO, L. J.; TAYLOR*, R. J. K.; Synthesis 2008, 23, 3846-3856; Dep. Chem., Univ. York, Heslington, York YO10 5DD, UK; Eng.) -Mais 14-100
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