Efficient syntheses of α-branched amines by three-and four-component C−H functionalization employing a diversifiable hydrazone directing group have been developed. The hydrazone in the α-branched amine products has been readily converted to multiple desirable functionalities such as a nitrile, a carboxylic acid, alkenes, and heterocycles using diverse heterolytic chemistry and homolytic transition metal-or photoredox-catalyzed processes. This study represents the first example of a fourcomponent C−H functionalization reaction.
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