The effects of a new steroid anaesthetic agent (CT1341) were studied in twenty volunteers divided into three groups. In group I, serial measurements were made of heart rate, blood pressure and respiratory rate. In group II, detailed haemodynamic studies were made in patients undergoing diagnostic cardiovascular investigations. These studies included measurement of cardiac output, stroke volume and arterial blood gases. In group HI, time from induction to "true recovery" was measured following a single intravenous injection of the drug. This agent produced a stable anaesthetic state in all cases. Anaesthesia was characterized by a rise in respiratory rate and pulse rate with a slight fall in systolic and diastolic blood pressure. A significant fall in Pa<>, occurred in those patients breathing air. The mean recovery time in six patients was 24.3 min. CT1341 produced safe and stable anaesthesia in all twenty cases and is worthy of further clinical trial. • CT1341 is manufactured by Glaxo Laboratories Limited, Greenford, Middlesex. 3a-hydroxy-5a-pregnane-ll,20 dione 0.9% w/v 21-acetoxy-3a-hydroxy-5o pregnane-11,20 dione 0.3% w/v Cremophor EL 20% w/v Sodium chloride 0.25% w/v Water for injection BP to 100% Throughout this paper the dosage of CT1341 will be expessed as ml of the above formulation. This paper reports the findings of a preliminary and limited clinical investigation conducted with the approval of the Committee on Safety of Drugs.
Nephrostomy has been the standard method of urinary diversion when placement of ureteral stents has failed in cancer patients. We describe our early experience with an alternative method of urinary diversion, the subcutaneous urinary diversion. This extra-anatomical urinary diversion was done in 5 patients during a 15-month interval. The diversion is created using a specially designed 7F double pigtail stent. The proximal end of the stent is inserted into the renal pelvis via a percutaneous nephrostomy puncture. A subcutaneous tunnel is created from the flank to the bladder down which the distal end of the stent is passed and via a suprapubic bladder puncture the stent is passed into the bladder. The stent is changed at 4-month intervals over a guide wire. Our early experience with this extra-anatomical method of urinary diversion suggests it to be a safe, effective and acceptable alternative to nephrostomy that improves quality of life.
Objective-To determine whether a swimmer's view or supine (trauma) oblique views are more likely to visualise the lower cervical spine when a lateral view fails to show the cervicothoracic junction. Design-A prospective study comparing two 20 week periods. In the first phase the swimmer's view was performed as an additional view when the cervicothoracic junction was not demonstrated. In the second phase paired supine oblique views replaced the swimmer's view. Results-230 patients were included in the first phase, of whom 60 required swimmer's views. In the second phase 62 of 197 patients required supine oblique views. Radiology analysis of 53 pairs of supine oblique views showed that the vertebral bodies were adequately demonstrated at the cervicothoracic junction in only 20 patients (38%) compared with 22 in the swimmer's group (37%). The facet joints and posterior elements were, however, clearly seen in 37 (70%) of the supine oblique patients compared with 22 (37%) of the swimmer's group (p < 0.001, x2 test). Exposure dose calculations showed a substantial reduction for a pair of supine oblique views (1.6 mGy) over a single swimmer's view (7.2 mGy). Conclusions-In injured patients for whom the standard three view series fails to demonstrate the cervicothoracic junction, swimmer's views and supine oblique views show the alignment of the vertebral bodies with equal frequency. However, supine oblique films are safer, expose patients to less radiation, and are more often successful in demonstrating the posterior elements. (7Accid Emerg Med 1998;15:151-154)
This report describes a patient with primary hyperparathyroidism who became spontaneously normocalcaemic preoperatively. This was due to infarction in a parathyroid adenoma. Plasma parathormone (PTH) levels were monitored pre- and postoperatively.
The chapter of knowledge is very short, but the chapter of accidents is a very long one.' LORD CHESTERFIELD 1753Each year brings an increase in the number of mishaps in anasthesia. So also does it bring an increase in litigation following these unfortunate incidents. In this paper I have recorded some of the recent accidents which have been brought to my notice. These are considered in four categories. FIG.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.