No abstract

The problem of frailty in kidney transplantation is an increasingly discussed topic in the transplant field, partially also generated by the multiple comorbidities from which these patients are affected. The criteria currently used to establish the presence and degree of frailty can be rapidly assessed in clinical practice, even in patients with chronic kidney disease (CKD). The main objectives of this work are: 1) to describe the method of evaluation and the impact that frailty has in patients affected by CKD, 2) to explore how frailty should be studied in the pre-transplant evaluation, 3) how frailty changes after a transplant and 4) the impact frailty has over the long term on the survival of renal transplant patients.

Kidney transplant recipients are a vulnerable population at risk of a life-threatening COVID-19 infection with an incidence of death four-times higher than in the general population. The availability of mRNA COVID-19 vaccines has dramatically changed the fate of this infection also within this fragile population. Transplanted patients have an impaired immunological response also to mRNA vaccines. In March 2021, however, we started a vaccination campaign. These preliminary results show that both the incidence of death and of hospitalization dropped from 13% to 2.4% and from 45% to 12.5% compared to the previous outbreaks reported by our group. In univariate analysis, two variables were associated with an increased risk of hospitalization: older age and dyspnea (p = 0.023, p < 0.0001, respectively). In multivariate analysis, dyspnea (p < 0.0001) and mycophenolate therapy (p = 0.003) were independently associated with the risk of hospitalization. The association was even stronger when the two variables were combined (p < 0.0001). Vaccinations did not reduce the incidence of COVID-19 infections among our transplanted patients, but provided certain protection that was associated with a significantly better outcome for this infection.

MRI is undoubtedly the cornerstone of brain tumor imaging, playing a key role in all phases of patient management, starting from diagnosis, through therapy planning, to treatment response and/or recurrence assessment. Currently, neuroimaging can describe morphologic and non-morphologic (functional, hemodynamic, metabolic, cellular, microstructural, and sometimes even genetic) characteristics of brain tumors, greatly contributing to diagnosis and follow-up. Knowing the technical aspects, strength and limits of each MR technique is crucial to correctly interpret MR brain studies and to address clinicians to the best treatment strategy. This article aimed to provide an overview of neuroimaging in the assessment of adult primary brain tumors. We started from the basilar role of conventional/morphological MR sequences, then analyzed, one by one the, non-morphological techniques, and finally highlighted future perspectives, such as radiomics and artificial intelligence.

&lt;p&gt;The Italian space industry, and specifically Leonardo S.p.A., has gained unique skills at an international level in the development of space-qualified power laser sources with for lidar Earth observation applications (Aeolus, EarthCARE). Moreover, Leonardo S.p.A. and the Italian optical industry, has a consolidated technical-scientific knowledge and consolidated experience in the design and development of lidar receiver sub-systems (telescopes, optical devices and sensors) with &amp;#160;space applications. The Italian Space Agency (ASI) intends to benefit from long-term expertise to design and develop a lidar system for Earth observation applications. Two separate feasibility studies, one focusing of technical aspects and one focusing on scientific aspects, are presently underway to define mission goals and a possible instrument layout.&lt;br&gt;CALIGOLA has a primary focus on the atmosphere, but also a strong focus on the study of the Ocean-Earth-Atmosphere system and the mutual interactions within it. Exploiting the three Nd: YAG laser emissions at 354.7, 532 and 1064 nm and the elastic (Rayleigh-Mie) and Raman lidar echoes from atmospheric constituents, CALIGOLA is conceived to carry out three-wavelength particle backscatter and depolarization ratio and two-wavelength particle extinction profile measurements from aerosols and clouds to be used to retrieve their microphysical and dimensional properties. Furthermore, measurement of the elastic backscattered echoes from the sea surface and the underlying layers, and their degree of depolarization, CALIGOLA will be exploited to characterize sea optical properties (ocean color) and the suspended particulate matter, which are needed to study the seasonal and inter-annual phytoplankton dynamics and to improve the understanding of the role of phytoplankton in marine biogeochemistry, in the global carbon cycle and in the response of marine ecosystems to climate variability. A specific measurement channel will be dedicated to fluorescence measurements from atmospheric aerosols and marine chlorophyll, for the purpose of aerosol typing and for characterizing ocean primary production. Aerosol fluorescence measurements at 680 nm/460 nm are also planned for the purpose of aerosol typing. CALIGULA will also allow accurate measurements of the small-scale variability of the earth's surface elevation primarily associated with variations in the terrain, vegetation and forest canopy height.&lt;br&gt;The CALIGOLA project is explicitly included the on-going Three-Year Activity Plan (2021-2023) of the Italian Space Agency, with a scheduled tentative launch window of 2026-2028. The considered strategy to develop the above described space lidar mission in such a short time relies on the maximum exploitation of subsystems already developed at national level for space applications, with a high TRL (TRL&gt;7), ultimately leading to a space mission with high impact and scientific timeliness. The Phase A study of the technological feasibility of the laser source is on-going, commissioned by ASI to Leonardo S.p.A., and scientific studies in support of the mission also on-going, with the University of Basilicata being the leading scientific institution. The Italian Space Agency is willing to pursue this mission in a coordinated way with one or more other European or extra-European Space Agencies, with a bilateral or multi-lateral contributed mission approach, and, in this regard, any interest from other Agencies is welcome and desired.&lt;/p&gt;