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Severe oral mucositis is a major cause of morbidity following allogeneic hematopoietic stem cell transplantation (AHSCT). Cryotherapy, that is, the application of ice chips on the mucosa of the oral cavity during the administration of antineoplastic agents, may reduce the incidence and severity of chemotherapy-related oral mucositis. In this multicenter randomized study, we addressed whether cryotherapy during MTX administration is effective in the prevention of severe oral mucositis in patients undergoing myeloablative AHSCT. One hundred and thirty patients undergoing myeloablative AHSCT and MTX-containing GVHD prophylaxis were enrolled and randomized to receive or not receive cryotherapy during MTX administration. The incidence of severe (grade 3-4) oral mucositis, the primary end point of the study, was comparable in patients receiving or not cryotherapy. Moreover, no difference was observed in the incidence of oral mucositis grade 2-4 and the duration of oral mucositis grade 3-4 or 2-4, or in the kinetics of mucositis over time. In univariate and multivariate analysis, severe oral mucositis correlated with TBI in the conditioning regimen and lack of folinic acid rescue following MTX administration. Thus, cryotherapy during MTX administration does not reduce severe oral mucositis in patients undergoing myeloablative allogeneic HSCT. Future studies will assess cryotherapy before allogeneic HSCT.

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During 25 October 2011, an extremely intense rainfall event occurred in Eastern Liguria and Northern Tuscany. Severe damages were registered in the Monterosso and Vernazza basins, located in the famous area of Cinque Terre, which have been affected by hundreds of landslides, mud flows, and erosions. The main feature of the Cinque Terre landscape is the presence of terraced cultivations on steep slopes facing the sea. The area represents a remarkable cultural landscape, is a National Park, and is included in the World Heritage List of the UNESCO. This work aims to analyze the effect of abandoned terraced land on hydrogeological risks and in landslide prevention, by comparing what happened in Cinque Terre to other experiences presented in scientific literature. The cessation of maintenance of dry stone terraces due to the crisis of traditional agriculture was identified as the main cause of failure during the heavy rainfall event. However, we found some contrasting and, in some cases, unexpected results in the literature regarding the effects of the vegetation that develops on abandoned terraces. This paper compares different results in order to better understand what the future of terraced landscapes is and which are the best management strategies for such complex and fragile territories. In particular, where they represent a cultural heritage and a resource for the rural economy.

Agricultural terraces are often subject to degradation issues related to water movement. A better understanding of the main hydrological processes that govern surface and subsurface water flow pathways and that are responsible for terrace failure and dry-stone wall collapse is essential for appropriate water resource management and rural landscape maintenance in terraced areas. However, a clear conceptualization of different hydrological functioning related to wall instability issues is still missing. In this study, we monitored a terrace system in a hilly site of central Italy cultivated with vineyards. We adopted a multidisciplinary approach based on soil analysis, different geophysical techniques, hydrological monitoring, high-resolution grid terrain analysis and field experiments (infiltration and flooding tests) aiming to: (i) obtain new information of terrace soil and subsoil structure; (ii) test the hypothesis on wall instability based on the formation of preferential flow and water accumulation behind the wall; and (iii) develop a conceptual model of water circulation in agricultural terraces. Our results indicate that terrace soil was highly heterogeneous, including discontinuities and piping systems that facilitated a rapid infiltration and the development of fast subsurface flow. Groundwater rise did not occur, as observed in other terraced sites, but infiltrated water accumulated behind dry-stone walls, increasing pore water pressure and inducing wall bulging and instability. Our findings provided new field evidences of water circulation and led to the definition of a novel paradigm of hydrological functioning of farming terraced systems for addressing more efficient management and maintenance issues in these vulnerable landscapes. Copyright © 2017 John Wiley & Sons, Ltd

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Haemorrhagic cystitis (HC) is a recognised complication in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). This study evaluates the incidence and severity of HC in patients undergoing allogeneic HSCT during hospitalisation and within the first 100 days following transplant, looking at the use of prophylaxis, management of HC, outcomes at 100 days post transplant, and to identify any correlations between development of HC and the different conditioning regimens for transplant or HC prevention methods used.ResultsFour hundred and fifty patients (412 adult and 38 paediatric) were enrolled in this prospective, multicentre, and observational study. HC was observed in 55 patients (12.2%) of which 8/38 were paediatric (21% of total paediatric sample) and 47/412 adults (11.4% of total adult sample). HC was observed primarily in the non-related HSCT group (45/55; 81.8%, p= 0.001) compared to sibling and myeloablative transplant protocols (48/55; 87.3%; p= 0.008) and with respect to reduced intensity conditioning regimens (7/55;12.7%).In 33 patients with HC (60%), BK virus was isolated in urine samples, a potential co-factor in the pathogenesis of HC. The median day of HC presentation was 23 days post HSCT infusion, with a mean duration of 20 days. The most frequent therapeutic treatments were placement of a bladder catheter (31/55; 56%) and continuous bladder irrigation (40/55; 73%). The range of variables in terms of conditioning regimens and so on, makes analysis difficult.ConclusionsThis multi-centre national study reported similar incidence rates of HC to those in the literature. Evidence-based guidelines for prophylaxis and management are required in transplant centres. Further research is required to look at both prophylactic and therapeutic interventions, which also consider toxicity of newer conditioning regimens.

Italian dry-stone wall terracing represents one of the most iconic features of agricultural landscapes across Europe, with sites listed among UNESCO World Heritage Sites and FAO Globally Important Agricultural Heritage Systems (GIAHS). The analysis of microclimate modifications induced by alterations of hillslope and by dry-stone walls is of particular interest for the valuation of benefits and drawbacks of terraces cultivation, a global land management technique. The aim of this paper is to perform a thermal characterization of a dry-stone wall terraced vineyard in the Chianti area (Tuscany, Italy), to detect possible microclimate dynamics induced by dry-stone terracing. The aerial surveys were carried out by using two sensors, in the Visible (VIS) and Thermal InfraRed (TIR) spectral range, mounted on Unmanned Aerial Vehicles (UAVs), with two different flights. Our results reveal that, in the morning, vineyard rows close to dry-stone walls have statistically lower temperatures with respect to the external ones. In the afternoon, due to solar insulation, temperatures raised to the same value for each row. The results of this early study, jointly with the latest developments in UAV and sensor technologies, justify and encourage further analyses on local climatic modifications in terraced landscapes.