A atividade fotodinâmica do cloro (5,10,15,20-tetrafenilporfirinato) de índio(III) (InTPP) in vitro foi investigado para possível uso em terapia fotodinâmica (PDT). O rendimento quântico de oxigênio singlete do InTPP (Φ ∆ = 0,72) em DMSO foi maior que da 5,10,15,20-tetrafenilporfirina (TPP) (Φ ∆ = 0,52). Os sítios de ligação entre os fotossensibilizadores e albumina bovina (BSA) são independentes e com células vermelhas de sangue humano (RBC) são cooperativos, com um e quatro sítios de ligação por molécula, respectivamente. As constantes de associação com BSA são (1,15 ± 0,07) × 10 5 e (2,6 ± 0,1) × 10 4 L mol -1 e com RBC são (2,40 ± 0,05) × 10 7 L mol -1 e (7,2 ± 0,2) × 10 4 L mol ) of photosensitizers were used. InTPP was 1.37-1.5 times more effective in the photooxidation of RBC than Photofrin®. Our results indicate that InTPP should be used in future studies of PDT.
In this study, we evaluated the photophysical properties of 5,10,15,20-tetrakis[4-(1,4,7,10,13-pentaoxacyclopentadecane-2-aminomethyl)2,3,5,6-(tetrafluoro)-phenyl]-porphyrin (H2C4P) and Zn(II)5,10,15,20-tetrakis[4-(1,4,7,10,13-pentaoxacyclopenta-decane-2-aminomethyl)2,3,5,6-(tetrafluoro)-phenyl]-porphyrinate (ZnC4P). We observed that these porphyrins have unique properties when compared with classical porphyrins. The porphyrins H2C4P and ZnC4P showed efficient transfer energy S1 to T1 by intersystem crossing with high and reasonable yields of triplet excited state and singlet oxygen production. These amphiphilic structures of these porphyrins could improve its localization in the tumor cells due to the presence of the crown ether in its framework. We also believed that the crown ether could modulate the change in ion homeostase (Ca(+2), K+, Na+) as already described by some new phthalocyanine dye. This fact makes us believe that it could be reasonably used as a photosensitizer for PDT purposes.
In this study, we evaluated the photophysical properties of 5, 10, 15, 20‐tetrakis[4‐(1, 4, 7, 10, 13‐pentaoxacyclopentadecane‐2‐aminomethyl) 2, 3, 5, 6‐(tetrafluoro)‐phenyl]‐porphyrin (H2C4P) and Zn(II)5, 10, 15, 20‐tetrakis [4‐(1, 4, 7, 10, 13‐pentaox‐acyclopenta‐decane‐2‐aminomethyl) 2, 3, 5, 6‐(tetrafluoro)‐phenyl]‐porphyrinate (ZnC4P). We observed that these porphyrins have unique properties when compared with classical porphyrins. The porphyrins H2C4P and ZnC4P showed efficient transfer energy S1 to T1 by intersystem crossing with high and reasonable yields of triplet excited state and singlet oxygen production. These amphiphilic structures of these porphyrins could improve its localization in the tumor cells due to the presence of the crown ether in its framework. We also believed that the crown ether could modulate the change in ion homeostase (Ca+2, K+, Na+) as already described by some new phthalocyanine dye. This fact makes us believe that it could be reasonably used as a photosensitizer for PDT purposes.
Ao meu marido, amigo e amor Denilson Que nesses 19 anos de união sempre esteve me incentivando, acreditando e sonhando comigo. Que me mostrou que a felicidade é uma trajetória e cada dia tem que ser especial. À minha filha Carolina Que sempre me ensinou a ser mais tolerante, a acreditar em pessoas e na vida. À minha filha Júlia Que enche nosso lar de alegria, amor e também de teimosia. Ao Pub (in memorian), menino da casa que amou muito a família. A Sophie, Fofinha e Snowbela pelo carinho. Às minhas irmãs Arteti e Elina, que sempre estão ao meu lado; e aos meus cunhados Léo e Serginho, que cuidam delas. À minha mãe Alice e meu pai Máximo pelo carinho. À minha sogra Dila, que é uma segunda mãe, e ao meu sogro Otávio, que sempre está ao nosso lado. Aos cunhados Daniel e Wanderson pela amizade e carinho. E finalmente à toda família que amo muito.
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