Introduction: Warfarin is the most frequently prescribed anticoagulant. Clinical treatment is demanding because of the narrow therapeutic range and considerable differences between the patients. The aim of this survey is to establish adherence to warfarin in subjects who have been prescribed warfarin as a long-term therapy.Methods: The survey included 30 subjects, and was conducted at local pharmacy store. Statistical processing was carried out using the SPSS (ver. 21.) software. Used for qualitative variables was the Chi-square test, and for quantitative ones the ANOVA test. Data were provided in the form of tables and charts. Level of significance was p=0.05.Results: The survey included 30 subjects, 14 men and 16 women. Of the total number of polled subjects, 15 were informed by a health care professional about the specificities of warfarin use, 7 said they were not informed, while 8 said they did not know. Most compliant in terms of regularly taking their medicines were pensioners, followed by the unemployed, χ2=13.231; p<0.05. The number of subjects within the expected therapeutic INR range was 22 (p<0.05).Conclusion: Strict compliance with the warfarin regimen is important in order to increase its effectiveness, extend the time and strengthen the intensity of anticoagulant action in the body. That is why the target groups of patients, who use warfarin, need additional information before and during therapy, in order to avoid side effects, and at the same time maintain therapeutic efficacy of the medicine throughout the treatment.
Evidence Based Medicine (EBM) is one of the modern systems of collecting, recording and using information and data related to medicine. The research was conducted in 2018 in several health institutions (health centers and hospitals) in Sarajevo Canton. The sample was made up of family doctors and other clinical specialties. The research results suggest the doctors in BiH are familiar with the concept of Evidence Based Medicine (EBM) andin their everyday work they apply relevant contemporary knowledge, national and international guidelines for the treatment and disease therapy. The most significant obstacle to more efficient management of medical information and the implementation of EBM in practice is the perception it would require additional time and incur significant cash expenditures to the doctors. In the future, doctors will increasingly be demanded to use advanced tools and modern techniques supporting them to make the most effective treatments on the basis of their own experience.
Results from the study suggest that basal-bolus regimen consisting of insulin glargine significantly improves glycaemic control without increasing hypoglycemia risk in DMT2 population with inadequate glycaemic control on previous premixed therapy.
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