Adipokines are molecules produced and secreted by adipose tissue and are linked to multiple malignancies. Adipokines can suppress or promote particular cell behaviors in different types of cancer. The aim of this study was to investigate the impact of chemotherapy on select adipokines in patients with colorectal cancer (CRC).Blood samples were collected from 42 patients with pathologically documented advanced CRC, who required palliative chemotherapy. Leptin, adiponectin, resistin and visfatin levels were measured by ELISA before and 3 months after the administration of chemotherapy. Among the 42 patients evaluated, 18 achieved a partial response (PR), 16 achieved stable disease (SD) and 8 patients experienced disease progression (PD).We found that 5-fluorouracil-based chemotherapy regimens significantly increased plasma levels of leptin and adiponectin and decreased plasma levels of resistin and visfatin in PR and SD patients, whereas the plasma levels of these molecules were not affected in PD patients. Furthermore, the mean plasma levels of leptin were significantly lower, and the mean plasma levels of resistin and visfatin were significantly greater in patients with PD compared with PR and SD both before and after chemotherapy treatment.We conclude that palliative chemotherapy in CRC patients, in addition to providing clinical benefits, positively affects cytokine production and secretion in PR and SD patients. Specifically, we found that palliative chemotherapy increased plasma levels of the anti-inflammatory adipokine adiponectin and decreased the plasma levels of visfatin and resistin, molecules known to promote angiogenesis and cancer cell proliferation in PR and SD patients. Moreover, the baseline values of leptin, visfatin and resistin might serve as prognostic indicators of a poor response to chemotherapy.
The present study was designed to investigate the role of postnatal fluoride intake on [3H]glucose uptake and transport in rat brain and peripheral tissues. Sodium fluoride (NaF) in a concentration of 10 or 50 ppm was added to the drinking water of adult Wistar rats. The control group received distilled water. After 4 weeks, respective plasma fluoride levels were 0.0541 ± 0.0135 μg/ml (control), 0.0596 ± 0.0202 μg/ml (10 ppm), and 0.0823 ± 0.0199 μg/ml (50 ppm). Although plasma glucose levels were not altered in any group, the plasma insulin level in the fluoride (50 ppm) group was elevated (0.72 ± 0.13 μg/ml) versus the control group (0.48 ± 0.24 μg/ml) and fluoride (10 ppm) group. In rats receiving fluoride for 4 weeks at 10 ppm in drinking water, [3H]glucose uptake was unaltered in all tested parts of the brain. However, in rats receiving fluoride at 50 ppm, [3H]glucose uptake in cerebral cortex, hippocampus, and thalamus with hypothalamus was elevated, versus the saline group. Fluoride intake had a negligible effect on [3H]glucose uptake by peripheral tissues (liver, pancreas, stomach, small intestine, atrium, aorta, kidney, visceral tissue, lung, skin, oral mucosa, tongue, salivary gland, incisor, molars, and jawbone). In neither fluoride group was glucose transporter proteins 1 (GLUT 1) or 3 (GLUT 3) altered in frontal cortex and striatum versus control. On the assumption that increased glucose uptake (by neural tissue) reasonably reflects neuronal activity, it appears that fluoride damage to the brain results in a compensatory increase in glucose uptake and utilization without changes in GLUT 1 and GLUT 3 expression.
Wprowadzenie i cel pracy. Zachowania zdrowotne są przejawem ukształtowanej przez środowisko (np. działania edukacyjne) postawy jednostki wobec zdrowia. Oprócz czynników zewnętrznych, pewną rolę w tym procesie wydają się odgrywać również cechy osobowości. Celem pracy była ocena zachowań zdrowotnych oraz zbadanie związku pomiędzy nimi a osobowością typu D i występowaniem objawów depresyjnych u studentek dietetyki. Materiał i metody. Grupę badaną stanowiły studentki kierunku dietetyka Wydziału Zdrowia Publicznego Śląskiego Uniwersytetu Medycznego. Badanie przeprowadzono w okresie od kwietnia do maja 2015 roku i objęło ono 151 respondentek. Zastosowano następujące narzędzia badawcze: inwentarz zachowań zdrowotnych (IZZ), skalę DS14 oraz skalę depresji Becka. Wyniki. Do osobowości typu D zaliczono 43% respondentek, 19% do typu nie-D, pozostałe osoby (38%) reprezentowały tzw. typ pośredni. Stwierdzono, że osobowość różnicuje nasilenie zachowań zdrowotnych, ponieważ osoby typu D charakteryzowały się gorszą dbałością o zdrowie niż typu nie-D. Wykazano również, że u studentek z osobowością typu D znamiennie częściej niż w typie nie-D występują objawy depresyjne (43,08% vs 7,14%). Dalsza analiza potwierdziła dodatkowo, że osoby z depresją charakteryzuje gorsza dbałość o zdrowie. Wnioski. Istnienie korelacji pomiędzy osobowością typu D a gorszymi zachowaniami zdrowotnymi oraz depresją wśród studentek dietetyki wskazuje na konieczność zintensyfikowania działań edukacyjnych ukierunkowanych na umiejętność radzenia sobie z negatywnymi stanami emocjonalnymi, które zaburzając szeroko pojętą homeostazę ustroju, mogą prowadzić do poważnych konsekwencji zdrowotnych w przyszłości.
The present study provides evidence that (1) an intact serotoninergic system is required for the adequate antinociceptive action of tramadol, and (2) the serotoninergic system exerts a negligible influence on acetaminophen-induced analgesia in rats. We hypothesize that similar abnormalities in nociception may occur in patients with 5-HT dysfunction (e.g. depression), so these results should be complied in analgesic dosage adjustment.
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