STRESZCZENIEWstęp. Wię za dło krzy żo we przed nie (ACL) na le ży do naj wa żniej szych struk tur sta bi li zu ją cych staw ko la no wy, a je go pod sta wo wą funk cją jest ogra ni cza nie przed niej trans la cji pisz cze li w sto sun ku do ko ści udo wej. ACL jed nak nie jest je dy nie me cha nicz nym ogra nicz ni kiem ru chu, lecz sta no wi wa żny kom po nent ukła du sen so mo to rycz ne go. Dla te go ce lem ni niej szej pra cy jest oce na kon tro li ner wo wo -mię śnio wej u osób po za bie gu re kon struk cji ACL, w opar ciu o prze bieg pro ce su utrzy my wa nia rów no wa gi dy na micz nej.Ma te riał i me to dy. Ba da nia mi ob ję to 26 oso bo wą gru pę (ACLR) o śred niej wie ku 28,4±6,3 lat, po prze by tym za bie gu ar tro sko po wej re kon struk cji ACL w okre sie 11-13 mie się cy przed ba da niem. Gru pę kon tro l ną (CTRL) stano wi ła 37 oso bo wa gru pa osób zdro wych. W ba da niach za sto so wa no sys tem Bio dex Ba lan ce Sys tem SD. Za da niem ba da nych osób by ło utrzy ma nie po zy cji sto ją cej obu nóż oraz jed no nóż na nie sta bil nym pod ło żu.Wy ni ki. Kon tro la sta bil no ści w po sta wie obu nóż w gru pie ACLR cha rak te ry zo wa ła się więk szy mi war to ścia mi cał ko wi te go in dek su sta bil no ści w sto sun ku do gru py CTRL (6,53±2,04 i 5,27±1,42, p<0,05). Ta kże war to ści ob serwo wa nych pa ra me trów w sta niu jed no nóż na koń czy nie ope ro wa nej by ły w gru pie ACLR istot nie więk sze niż w grupie kon tro l nej, od po wied nio 9,73±2,55 i 7,23±1,48 dla koń czy ny do mi nu ją cej, 9,42±2,38 i 5,64±1,51 dla koń czy ny nie do mi nu ją cej przy p<0,05.Wnio sek. W okre sie ro ku od wy ko na ne go za bie gu re kon struk cji ACL, pod czas wy ko ny wa nia za dań ru cho wych wy ma ga ją cych znacz ne go za an ga żo wa nia ukła du sen so mo to rycz ne go, wi docz ne są istot ne de fi cy ty w kon tro li nerwo wo -mię śnio wej.Słowa kluczowe: ACL, sensomotoryka, propriocepcja, równowaga, stabilność posturalna SUMMARY Background. The anterior cruciate ligament (ACL) is one of the most important stabilisers of the knee joint. The key role of ACL is to resist anterior translation of the tibia in relation to the femur. At the same time, ACL does not only perform a mechanical limiting function, but is also an important component of the sensorimotor system. The aim of this study was to assess neuromuscular control in patients after ACL reconstruction by evaluating the maintenance of dynamic balance.Material and methods. Twenty-six patients (aged 28.4±6.3 years) after ACL reconstruction (ACLR group) were enrolled. All patients had undergone arthroscopic reconstruction of ACL, and were recruited to the study 11-13 months after the surgery. Thirty-seven healthy individuals served as a control group (CTRL). The maintenance of the single-leg and two-leg standing position on an unstable surface was assessed using the Biodex Balance System SD.Results. The ACLR group differed from the control group in the values of the overall stability index (p<0.05; 6.53±2.04, and 5.27±1.42, respectively) when stabi...
BackgroundMajor symptoms of chronic obstructive pulmonary disease (COPD) are chronic bronchitis and emphysema leading from lung tissue destruction, that is an effect of an imbalance between metalloproteinases (MMPs) and their tissue inhibitors activity. As potential factor involved in this COPD pathogenesis, MMP-12 is considered. We investigated the role of genetic polymorphism and protein level of MMP-12 in the COPD development among Poles.MethodsWe analyzed − 82 A > G SNP in the promoter region of MMP-12 gene (rs2276109) among 335 smoked COPD patients and 309 healthy individuals, including 110 smokers. Additionally, 60 COPD patients and 61 controls (23 smokers) were tested for serum levels of MMP-12 using ELISA. All subjects were analyzed for lung function using spirometry (FEV1% and FEV1/FVC parameters).ResultsWe observed that -82G allele and -82GG homozygous genotype frequencies of the SNP rs2276109 were significantly lower in COPD patients than in controls (12.5% vs 16.9%, respectively; χ2 = 4.742, p = 0.02 for allele and 0.5% vs 3.9%, respectively; χ2 = 9.0331, p = 0.01 for genotype). Moreover, −82G allele was more frequent in controls smokers than in non-smokers (22.3% vs 14.1%, χ2 = 6.7588, p = 0.01). Serum level of MMP-12 was significantly higher in COPD patients than in controls groups (6.8 ng/ml vs 3.3 ng/ml, respectively; F = 7.433, p < 0.0001), although independently of analyzed gene polymorphisms. Additionally, no correlation between parameters of lung function (FEV1% and FEV1/FVC) and protein level was found.ConclusionsWe found that -82G allele of SNP rs2276109 was associated with reduced risk of COPD, and COPD patients released more MMP-12 than healthy individuals, but independently on this SNP.Electronic supplementary materialThe online version of this article (10.1186/s12881-019-0751-9) contains supplementary material, which is available to authorized users.
ObjectiveThe elderly are particularly vulnerable to degenerative diseases, such as circulatory and respiratory system and vascular system diseases. The objective of this study was therefore to evaluate the distribution of temperature and the dynamics of venous blood flow in the lower limbs (LLs) and to assess the interdependence of these parameters in terms of the somatic components in males and females participating in activities at the University of the Third Age.Materials and methodsThe study included 60 females (mean age 67.4 years) and 40 males (mean age 67.5 years). A body composition assessment was performed using the bioimpedance technique – Tanita BC-418MA. The following parameters were examined: fat%, fat mass, fat-free mass, and total body water. The minimal, maximal, and mean temperature values and their distributions were examined using infrared thermographic camera VarioCAM Head. Measurements of the venous refilling time and the work of the LL venous pump were examined using a Rheo Dopplex II PPG.ResultsIn males, the mean value of the right LL temperature was 30.58 and the mean value of the left LL was 30.28; the P-value was 0.805769. In females, the mean value of the right LL temperature was 29.58 and the mean value of the left limb was 29.52; the P-value was 0.864773. In males, the right limb blood flow was 34.17 and the left limb blood flow was 34.67; the P-value was 0.359137. In females, the right limb blood flow was 26.89 and the left limb blood flow was 26.09; the P-value was 0.796348.ConclusionResearch results showed that the temperature distribution and the dynamics of blood flow are not significantly different between the right and left extremities in both males and females. However, significant temperature differences were found between the gender groups. Significantly higher temperature values in both the right and left extremities were recorded in males than in females.
Background: The aim of the study was to assess lower limb function in response to two cardiac rehabilitation (CR) protocols after coronary artery bypass surgery with saphenous vein grafting. Methods: Clinically-stable male patients aged 50–70 years were recruited 4 weeks post-surgery in which to group. Group I (n = 47) receive standard CR in a hospital setting for 3 weeks and Group II (n = 14) receive CR with a resistance training component in an outpatient setting for 8 weeks. Measures included body mass and composition, lower limb temperature distribution, lower limb hemodynamics, and dorsal and plantar flexor muscle strength. Results: Average temperature of the operated limb decreased only in Group II after cardiac rehabilitation. Venous blood flow improved in both groups as evidenced by increased blood refilling time. Isokinetic strength was greater in Group I. Conclusions: The results suggest a 3-week intensive CR protocol to be most effective in restoring lower limb function in CABG patients after saphenectomy.
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