Overall prognosis for patients with oral squamous cell carcinomas (OSSC) is still unfavourable. However, there is a hope that a novel diagnostic method may establish better cancer biology characteristics. The aim of this study was to evaluate the isotope ratio of nitrogen and carbon in OSSC as compared to margin and healthy tissue. A total of 18 patients with OSSC were included in the study. Specimens collected covered: four tumour, four margin and two healthy oral mucosa samples. The samples underwent further procedures: lyophilization and isotope ratio mass spectrometry. Measurements of the ratio of stable isotopes of nitrogen 15N/14N and carbon 13C/12C were performed. It is noticeable that the highest average nitrogen concentration was observed in tumour 12 ± 0.4% and the lowest in healthy tissues 8 ± 0.9% (p < 0.00001). The highest average carbon content was observed in healthy tissues 57 ± 2.2% and the lowest in tumour 46 ± 1.3% (p < 0.00001). Moreover, values of 15N/14N expressed in delta notation were the highest in healthy tissues 9.84 ± 0.61 and the lowest in tumour 8.92 ± 0.58. Values of 13C/12C tended to be higher in tumour −22.2 ± 0.89 and the lowest in healthy tissues −23.7 ± 1.2. Tumour tissues differ in isotopic composition from tissues taken from margin and healthy tissues taken from distant oral mucosa.
Young men constitute the main group of cyclists in Poland. The risk factors for bike-related accidents in our study proved to be: educational level (secondary education and incomplete higher education), number of children (having at least 3 children), frequency of using a bike (the more often, the more injuries), type of bike used (mountain bikes and fold-up bikes), and frequency of using a helmet (using helmets was correlated with a higher rate of injuries). The upper and lower extremities were the most common location of injuries.
Background. Cycling is a very popular type of activity in our times. People of all ages use bikes for many purposes like sport, entertainment or as means of transport. Unfortunately, this activity exposes cyclists to more frequent injuries of the face and head region.
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