Purpose/Background: This study examined the effect of myopic defocus on visual acuity (VA) over time, with attention being paid to the first point at which blur adaptation had a significant and measurable effect on defocused VA. Visual acuity was sampled at a higher rate than previous studies in order to assess the time course of blur adaptation processes in myopic and emmetropic observers. Methods: Participants were 24 normally-sighted observers (12 emmetropes and 12 myopes, median age: 22.5 years). All ametropic participants wore their full refractive correction throughout the experiment. 1 D and 3 D of myopic defocus were introduced in two separate, randomised sessions. Visual acuity was measured using Test Chart 2000 at 2 min intervals over a 30 min session whilst looking through defocus lenses. Recovery clear VA was also measured every 2 min for a further 20 min. Results: Defocused VA was found to improve significantly within 4 min after the introduction of defocus for both 1 D (P < 0.0001) and 3 D conditions (P < 0.0001). The improvements reached a plateau shortly after, with no significant further improvements in defocused VA after 6 min. There were no significant differences found in the temporal blur adaptation profiles between emmetropes and myopes (P = 0.267). Data were fitted with an exponential decay function; the lowest R 2 value for this fit was 0.95. Conclusions: Blur adaptation has a clinically significant and measurable effect on VA within 4 min of exposure to defocus. This finding indicates that the visual system instigates the neural compensatory mechanisms shortly after the appearance of defocus. Our results relate particularly to real-life vision of uncorrected myopes or myopes who remove their correction for part of the day.

Neural adaptation to blur improves VA under defocused conditions in the parafovea as well as the fovea, indicating that the underlying compensatory mechanism acts across a range of spatial scales and independently of retinal eccentricity. Foveal and parafoveal blur adaptation does not vary with refractive error.

Normal upward attentional bias increases with aging, possibly due to an age-related reduction of the dorsal attentional stream that is responsible for the allocation of downward attention. (JINS, 2018, 24, 1121-1124).

Patients with ESRD receiving dialysis appear to have an impaired ability to correctly allocate their spatial attention (spatial neglect). Although the reason for the patients' leftward bias needs to be elucidated, ESRD and/or dialysis may have induced right frontal-subcortical dysfunction that disinhibited the right parietal lobe, producing a left-sided attentional bias. Further studies are needed to test this hypothesis.