The paper presents the results of the application of the plasmolifting technique in the treatment of various types of musculoskeletal pathology and analyzes the possible mechanisms of the positive therapeutic effect of this technique. It is suggested that its success is in direct proportion to the composition of the tissues that make up a particular articular formation. It is supposed that the conditions for the positive therapeutic effect of the platelet auto-suspension technique include, first of all, the presence of a branched network of capillaries, which provides sufficient blood supply and, as a result, access to the sanitized tissue of granulocytic cells. The second condition is the presence of connective tissue formations containing basophils and mast cells, which, together with the endothelium of the above capillaries, secrete a sufficient amount of cytokines that trigger the therapeutic effect of this manipulation. A number of recommendations were made to increase the sanitizing effect of the plasmolifting technique on a specific joint formation.
The authors investigated the involvement of the adenosine triphosphate (ATF) in the mechanisms of plasticity in the striated muscle in condition of protein sensitization. Contractile function and non-quantum secretion of the acetylcholine in the endplate zone were studied in isolated skeletal muscles of mouse legs (musculus soleus and musculus extensor digitorum longus) and strips musculus diaphragm. The authors studied the soleus and diaphragm dynamics of the force vector of muscle contraction after effects of exogenous adenosine triphosphate correlated with changes non-quantum secretion of acetylcholine in all the experimental models. However, the extent of these changes in sensitized animals is less pronounced than in the controls. It is suggested that adenosine is a party change mechanisms and functional properties soleus and diaphragm at the protein sensitization. The basis of the development of resistance, stability to long as the external stress, and at the initial stages of the experimental allergic these muscles are dependent adenosine mechanisms regulating their sensitivity to acetylcholine. These processes provide a reduction in respiratory muscle fatigue in hypoxia that occurs in asthma, chronic obstructive pulmonary disease and broncho-spastic syndrome, as well in increase their performance during prolonged physical activity. The reasons for changes in the force reduction extensor digitorum longus at a protein sensitization doesn’t associated with the mechanisms of muscle excitation mediated by adenosine triphosphate.
The state of the contractile function of transversely striated locomotor muscles under conditions of allergic reorganization remains relevant for modern sports medicine. In particular, it is known that the mandatory vaccination of athletes before the competition leads to changes in the state of the muscular system. The mechanisms of these changes are not fully understood. In the presented work, the following research methods were used: the registration of: a) the contractile function of various locomotor «fast» and «slow» muscles of the mouse in vitro on humoral initiators of contraction — carbacholine (CCh) and potassium chloride (KCI); b) indicators of the systems of pro- and antioxidant balance in the blood and in the tissues of these muscles and the determination of the level of malondialdehyde (MDA) in them. The differences in the ratios of the dynamics of the contraction force and the MDA level in both muscles demonstrate the degree of their resistance to oxidative stress, which determines the differences in the mechanisms of their adaptation to allergic reorganization. The materials of the article can be used to correct the function of locomotor muscles during vaccination, as well as to determine the strategy of therapeutic action, taking into account their fiber composition. The purpose of the article is to determine the mechanisms of adaptation of skeletal muscles (SM) of the mouse («fast» (m.EDL) and «slow» (m.Soleus)) during allergic reorganization.
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