A novel recyclable prolinamide-derived ionic-liquid-supported organocatalyst of asymmetric cross-aldol reactions in aqueous medium has been developed. In its presence, aromatic aldehydes react with cyclic or linear ketones to afford chiral aldol adducts in moderate to high yields and with ex-
Mono-and Bis-Aldol Reactions in the Presence of Water. -A novel recyclable prolinamide-derived ionic-liquid-supported organocatalyst of asymmetric cross-aldol reactions in aqueous medium is developed. In its presence, aromatic aldehydes react with cyclic or linear ketones to afford chiral aldol adducts in moderate to high yields and with excellent diastereo-and enantioselectivities that do not tend to decline over ten recycles of the catalyst. Furthermore, this catalyst allows a highly enantioselective synthesis of linear bis-aldols in aqueous medium. -(KUCHERENKO, A. S.; GERASIMCHUK, V. V.; LISNYAK, V. G.; NELYUBINA, Y. V.; ZLOTIN*, S. G.; Eur. J. Org. Chem. 2015, 25, 5649-5654, http://dx
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