In the period between 1 January 1978 and 1 January 2004, 85 patients with hypopharyngeal squamocellular carcinoma were admitted at the Department of Esophagogastric Surgery in Belgrade. Among them, only 46 patients (54.1%) had radical surgical en-block resection and functional neck dissection, and they were included into an historical cohort study. In 40 patients a pharyngolaryngoesophagectomy was performed using for reconstruction, stomach tissue in 29 and colon tissue in 11 patients. Since 1996, in six patients with localized hypopharyngeal carcinoma pharyngolaryngectomy was performed with resection of cervical esophagus and free jejunal graft interposition. The overall incidence of morbidity was 50.0% and the overall mortality rate was 13.0% (6 patients). Mean hospital stay was 35 days (range, 18-78 days). The median survival of patients was 26 months, and overall 5-year survival rate was 26.5%. At present, surgery seems to be the appropriate therapeutic choice for patients with advanced hypopharyngeal carcinoma, providing a definitive palliation of dysphagia and relatively good long-term survival. At our Institution, after pharyngolaryngoesophagectomy, reconstructive method of choice is gastric 'pull-up', and the colon is used only when stomach tissue is not available, that is, previous gastric resections, inappropriate blood supply, synchronous gastric carcinoma and so on. Recently, pharyngolaryngectomy and free jejunal transfer has become the standard technique in patients with small carcinomas (up to 3 cm) confined to the hypopharynx in the absence of synchronous esophageal and/or gastric carcinoma.

Indicating further long-term studies, 3 years after the operation limited hiatal dissection compared to complete obtains better reflux control in achalasia patients, regardless of Dor's fundoplication.

HALO RFA is a safe procedure, with high rate of success in complete eradication of BE in symptomatic GERD patients. LNF provides good protection for neosquamous epithelium and in selected group of patients could be offered as a first line of treatment after HALO RFA.

This dissertation has originated from many years of research on the issue of propulsion of inland-waterway self-propelled cargo vessels (IWV). Hydrodynamic effects stemming from complex conditions related to IWV navigation make selecting the appropriate propulsion system during the project phase a very complex and challenging task. A particularly important issue is the scarcity of methods for determining the influence of waterway restrictions on hydrodynamic efficiency. This produces difficulties when determining the overall energy efficiency of these ship types. Based on all the data collected from the available references and reports, a database was created containing basic dimensions and results of power absorption measurements of many different types of IWV. The data served as a basis for research devoted to navigation-related hydrodynamic effects. During the course of the research, numerous direct measurements of ship power absorption in realistic conditions were performed. This enabled the expansion of the aforementioned base, but also indicated the complexity of measurement methods, which occasionally produce considerable differences between the available results of power absorption measurements of the same ship, but also between examinations of models and corresponding full-scale IWV. Based on the available results of model-scale examinations, a mathematical model was developed that can determine the power required for achieving the desired speed, on the basis of the known ship dimensions and displacement, as well as waterway restrictions. The analysis of full-scale ships examinations and comparisons of model and full-scale measurements, along with the application of existing methods of determining the effects of external influences, led to the formulation of recommendations for estimating power vi power margin. A method was indicated, based on the examination of full-scale ships, whereby the propulsion coefficients depending on waterway restrictions can be determined. Resulting from the derived conclusions, a method was suggested that can determine the energy efficiency index and establish the reference curve/curves for inland waterway self-propelled cargo vessels.

Three years after NF, successful symptomatic and functional outcome was achieved in analyzed groups of patients with erosive esophagitis regardless of IEM subtype.

The results of this study show that the open surgical procedures are safe and effective in the treatment of ZD. Cricopharyngeal myotomy remains the essential focus of treatment, while the choice of resecting or suspending the diverticulum is brought upon its size. Complete preoperative investigation must be conducted in ZD patients, and the role of pathologic GER must be taken into account when we discuss the origin of this disorder.

Gastroesophageal reflux disease (GERD) is a common disorder, known to affect about 20% of the Western population. Although conventional medical or surgical treatment has proven effective, there is certainly room for improvements. As only 10% of GERD patients are finally treated by antireflux surgery, a large therapeutic window exists. This treatment gap consists of patients who are not effectively treated with proton pump inhibitor but do not want to run the potential risks of conventional surgery. During the last two decades, several novel and intriguing options for the surgical treatment of GERD have been introduced and found their way into clinical use. The following summary will give an update of certain alternative therapeutic options to treat GERD or its pathological consequences.

We present a case of a 41-year-old male patient who, 1 year after transhiatal esophagectomy and transmediastinal gastroplasty for an adenocarcinoma of the distal esophagus, presented with an isolated metastasis in the choroids of the left eye. Because of pains caused by secondary glaucoma, enucleation of the left eyeball had to be performed as the treatment of choice. At 1 year after surgery of the eye, the secondaries in both adrenal glands were revealed. Despite the applied chemotherapy, the patient died with signs of generalized disease 3 years after the initial surgery.