Introduction/Objective The incidence of both melanoma and non-melanoma skin cancers (NMSC) has been increasing over the past decades worldwide. NMSC is the most common cancer in white population and melanoma is one of the deadliest cancers today. The objective of the paper was to determine trends in age-standardized incidence rates of NMSC and melanoma in central Serbia from 1999 to 2013. Method A descriptive epidemiological study was done. Data about incidence for NMSC and melanoma were obtained from the Serbian Cancer Registry and data about population originating from 1991, 2001, and 2011 censuses. Crude incidence rates were calculated per 100,000 inhabitants. Direct method of standardization was performed with the world population as the standard. Trend lines were estimated using linear regression. Results During a 15-year period, the total number of new NMSC cases was 41,719 [21,690 (52%) in men and 20,029 (48%) in women]. There were 5,781 new cases of melanoma [2,969 (51.4%) in men and 2,812 (48.6%) in women]. A significantly increasing incidence trend for NMSC both in men (y = 0.617x + 24.29, R 2 = 0.500) and women (y = 0.672x + 0.670, R 2 = 0.670) was determined. In the same period, a statistically significant increase of incidence trend for melanoma was determined in men (y = 0.111x + 3.708, R 2 = 0.384) and in women (y = 0.098x + 3.375, R 2 = 0.409). NMSC was registered in persons of all ages. NMSC incidence increased rapidly in persons older than 50 years. Melanoma predominates in children and adolescents and is registered more frequently than NMSC in persons bellow 60 years of age. Conclusion Our findings showed significantly increasing trend of age-standardized incidence rates for both NMCC and melanoma. In the observed period, there were 7.2 times more new cases of NMSC than melanoma in the population of central Serbia. There were more registered new cases of NMSC and melanoma in men than in women. Screening of skin cancers and earlier diagnosis may improve treatment and prognosis.

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There is a concern regarding the high incidence of coronary heart disease (CHD) among patients with diabetes mellitus (DM) type 2 since it is a leading cause of mortality in those patients. Exercise treadmill test (ETT) is proposed as a suitable, non-invasive method for identifying asymptomatic patients with ischemic changes, who would benefi t from pharmacological treatment, thus contributing to a reduction of adverse cardiovascular events. Th erefore the objective of our study was to evaluate myocardial ischemia in asymptomatic patients with DM type 2 by performing ETT. Th e present investigation was conducted in Health Center Pozega during the year 2018. 40 insulin-dependent, aged 33.05 ± 2.01 years, with DM type 2 were included in the study. Th ey had nor history nor symptoms of cardiac disease. All patients underwent ETT according to Bruce protocol, while 12- lead ECG was recorded and blood pressure was monitored. All patients had negative ETT results. Also no ST segment depression, no signs of insuffi ciency of peripheral circulation, no changes in heart rhythm, no symptoms by the central nervous system were observed. Additionally response of heart rate and blood pressure to exercise was within physiological range. Th ese promising fi ndings indicate that diabetes didn’t alter myocardial integrity and function, thus suggesting that coronary reserve in examined patients was preserved.

Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system characterized by multiple disseminated lesions. The pathogenesis of this disease is still insufficiently clarified, and the course of the disease is unpredictable. It happens that severe relapses do not respond to drug therapy and in such cases it is recommended therapeutic plasma exchange (TPE). We present a young man with severe motor relapse, weakness of the left leg, pronounced tremor of the right arm, unstable gait and bilaterally reduction of vision. Brain magnetic resonance imaging showed a large number of chronic demyelinating lesions of the white mass, numerous were merged, with signs of brain reduction. The patient underwent five cycles of TPE, which were conducted every other day. Although TPE led to a disturbance of the hemostasis status and some biochemical parameters, the patient’s response to the applied therapy was good. The improvement of the patient’s condition was reflected through the return of vision and a moderate reduction in neurological deficit. Despite the fact that therapeutic plasma exchange can cause some complications, it should be considered when drug therapy does not lead to improvement in these patients.

Hepatitis A je akutno virusno oboljenje jetre prouzrokovano virusom hepatitisa A(HAV).U mnogim područjima sveta predstavlja značajan epidemiološki problem, a infekcija se najčešće prenosi kontaktom, ređe kontaminiranom vodom i hranom. Osnovni cilj rada je identifikacija najvažnijih epidemioloških karakteristika hepatitisa A u srpskim sredinama Kosova i Metohije. U radu korišćeni su podaci odnosno prijave zaraznih bolesti, izveštaji o kretanju zaraznih bolesti (sedmodnevni, mesečni, godišnji) Zavoda za javno zdravlje Priština sa sedištem u Kosovskoj Mitrovici. U radu je korišćena epidemiološka srudija preseka (cross sectional). U periodu od 2003-2015. god. na Kosovu i Metohiji ( srpske sredine) registrovano je 223 slučajeva hepatitisa A. Prosečna incidencija u posmatranom periodu je 11,03 /100000. Analiza uzrasne distribucije pokazala je da su najčešće obolevale osobe uzrasta od 15-19 godina, a najređe osobe uzrasta 50-59 godina. Hepatitis A se javlja tokom čitave godine pokazujući sezonske varijacije. Trend stope obolevanjaje pokazuje negativni trend sa smanjenjem broja obolelih na teritoriji Kosova i Metohije. Na osnovu rezultata našeg istraživanja može se zaključiti da je hepatitis A značajan javnozdravstveni i socioekonomski problem. U cilju prevencije hepatitisa A važno je nastaviti sa poboljšanjem higijensko-sanitarnih uslova života kao najbolje opšte preventivne mere.Ključne reči: hepatitis A, epidemiološke karakteristike, Kosovo i Metohija UVODHepatitis A je akutno virusno oboljenje jetre prouzrokovano virusom hepatitisa A(HAV).U mnogim područjima sveta predstavlja značajan epidemiološki problem, a infekcija se najčešće prenosi kontaktom,ređe kontaminiranom vodom i hranom.Kod dece školskog uzrasta i mlađih odraslih osoba se češće registruje oboljenje.[1] Kod mlađe dece je infekcijea češće asimptomatska.Žutica se javlja samo kod 10%inficirane dece uzrasta do šest godina,a kod starijih se ikterus javlja u više od 70% slučajeva.Pa su zbog toga deca najvažniji rezervoari infekcije. [2] Na jednom području, epidemiološka situacija hepatitisa A je odraz standarda,uslova života i higijenskih prilika.Infekcija hepatitisa A je česta u nerazvijenim sredinama, a incidencija je niska zbog prokuženosti stanovništva u najranijem uzrastu.Kontinuirani pad incidencije beleži se u razvijenim zemljama,a hepatitis A se ljavlja u obliku pojedinačnih slučajeva i manjih epidemija u kolektivima,porodicama ,i kod putnika u među-narodnom saobraćaju koji borave u endemskim područjima. [1] Epidemiološka situacija hepatitisa A u mnogim evropskim zemljama je povoljna. U 26 evropskih zemalja, tokom 2006.godine prijavljeno je 20 066 slučajeva hepatitisa A. Incidencija od 3,9/100 000 je višestruko niža od incidencije registrovane pre deset godina (15,1/100 000).Najveći broj slučajeva prijavljen je u Bugarskoj (94,1/100 000), slede Rumunija (24,8/100 000) i Slovačka (8,6/100 000), dok je u ostalim zemljama Evropske unije zabeležena incidencija ispod 3/100 000. [3] CILJ RADA Osnovni cilj rada je identifikacija najvažnijih epidemioloških kar...