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Highlights COVID-19 disease is associated with stroke All strokes subtypes are seen in association with COVID-19, with ischemic stroke being most prevalent The most common etiology for ischemic stroke in SARS-CoV2 infection is cryptogenic Sex plays an important role in stroke outcomes in patients with COVID-19 disease Males have higher rates of ICU admission, in-hospital complications and more likely to have worse outcome at hospital discharge compare with females

Background: COVID-19 has been associated with increased risk of venous and arterial thromboembolism including ischemic stroke. We report on patients with acute ischemic stroke and concomitant COVID-19 in a diverse patient population. Methods: This is a retrospective analysis of patients hospitalized with acute ischemic stroke (AIS) and COVID-19 to our comprehensive stroke center in Chicago, IL, between March 1, 2020, and April 30, 2020. We reviewed stroke characteristics, etiologies, and composite outcomes. We then compared our cohort with historic patients with AIS without COVID-19 admitted in the same time frame in 2019 and 2020. Results: Out of 13 patients with AIS and COVID-19, Latinos and African-Americans compromised the majority of our cohort (76.8%), with age ranging from 31-80 years. Most strokes were cortical (84.6%) and more than 50% of patients had no identifiable source, and were categorized as embolic stroke of unknown source (ESUS). A trend toward less alteplase administration was noted in the COVID-19 stroke patients compared to the non-COVID group from 2020 and 2019 (7.1 vs. 20.7% p 0.435 and 7.1 vs. 27.2% p 0.178). Endovascular thrombectomy was performed in 3 (23%) patients. Systemic thrombotic complications occurred in 3 (23%) COVID-19 AIS patients. Median National Institutes of Health Stroke Scale and modified Rankin Scale at discharge were 11 (IQR 4-23) and 4 (IQR 3-4), respectively. In the logistic regression model corrected for age and sex, COVID-19 was associated with discharge to mRS > 2 (p 0.046, OR 3.82, CI 1.02-14.3). Eight patients (63.8%) were discharged home or to acute rehabilitation, and two deceased from COVID-19 complications. Conclusion: AIS in the setting of COVID-19 is associated with worse outcomes, especially among African-American and Latino populations. Large vessel disease with ESUS was common suggesting an increased risk of coagulopathy and endothelial dysfunction as a potential etiology.

A set of hybrid composite materials based on a PP matrix with multiwalled CNTs and clay particles is prepared and characterized. The incorporation of clay particles into a percolated composite with 3 wt% CNT disrupts the percolation, decreasing dramatically the electrical conductivity. As expected for layered fillers, PP/CNT/clay hybrid composite materials and PP/clay composites display increases as high as 100 °C in the temperature for the maximum rate of weight loss. Surprisingly, these temperatures are just slightly higher than those of PP/CNT composites. PP/CNT composites display viscosities that are considerably lower than those of PP/clay composites. A synergistic effect of both fillers is observed in the viscoelastic response of PP/CNT/clay materials.

BackgroundThere is a paucity of data and a belief that endovascular thrombectomy (EVT) has low efficacy for acute ischemic stroke (AIS) in patients with cancer. We aimed to critically compare the clinical outcomes of EVT for AIS in patients with and without cancer.MethodsRecords of all patients undergoing EVT for AIS between January 2015 and 2020 were screened for cancer at the time of EVT. Active cancer was defined as patients who were diagnosed with cancer and were undergoing or refused treatment for that cancer. Baseline modified Rankin Scale (mRS), age and sex were used in a 1:5 propensity score matching ratio. After matching we evaluated for any change in the National Institutes of Health Stroke Scale (NIHSS) from baseline to discharge, hemorrhagic transformation (HT), and 90-day mRS and mortality.ResultsThere were 19 patients with cancer and 95 matched controls. The mean±SD age was 70.89±11.16 years, and 17 (89.47%) were female. The baseline NIHSS was 22±7.5 and baseline mRS was 1 (IQR 1). There was no significant difference in change in baseline to discharge NIHSS, 90-day mRS or mortality; 90-day mRS 0–2 was 45.2% in the non-cancer group versus 46.7% in cancer group (p=0.54). HT was significantly higher in patients with cancer (57.89% vs 6.49%, p<0.001).ConclusionsIn propensity matched analysis of patients undergoing EVT for AIS with and without cancer, 90-day functional outcomes and mortality were similar. However, there was a significantly higher rate of HT in cancer patients.

SummaryObjectives: The main objective of this study is to learn more on the image use and search requirements of radiologists. These requirements will then be taken into account to develop a new search system for images and associated meta data search in the Khresmoi project. Methods: Observations of the radiology workflow, case discussions and a literature review were performed to construct a survey form that was given online and in paper form to radiologists. Eye tracking was performed on a radiology viewing station to analyze typical tasks and to complement the survey. Results: In total 34 radiologists answered the survey online or on paper. Image search was mentioned as a frequent and common task, particularly for finding cases of interest for differential diagnosis. Sources of information besides the Internet are books and discussions with colleagues. Search for images is unsuccessful in around 25% of the cases, stopping the search after around 10 minutes. The most common reason for failure is that target images are considered rare. Important additions for search requested in the survey are filtering by pathology and modality, as well as search for visually similar images and cases. Few radiologists are familiar with visual retrieval but they desire the option to upload images for searching similar ones. Conclusions: Image search is common in radiology but few radiologists are fully aware of visual information retrieval. Taking into account the many unsuccessful searches and time spent for this, a good image search could improve the situation and help in clinical practice. Methods Inf Med 6/2012 539

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