Resumen -El objetivo de este trabajo fue comparar la variabilidad, diversidad y distancias genéticas entre cerdos criollos, Pelón Mexicano (CPM) y Cuinos (CC), con Yorkshire, cuanto a los genes candidatos CAST, DECR1, HAL, HFABP4, LEP, LIPE, MCR4, MYOG, RN Gene and genotypic frequencies, heterozygosity, genetic distances and filogenetic trees between breed groups were analyzed. In the comparison among the three breeds, the allelic and genotypic frequencies were different for CAST, DECR1, HFABP4, LEP, MCR4 and CHX. For LIPE, CC pigs were similar to Yorkshire; while for MYOG, the CPM were similar to Yorkshire breeds. There were no differences in the genic and genotypic frequencies for HAL and RN genes between Creole and Yorkshire populations. The Yorkshire breed had higher favorable allele frequency for CAST, LIPE, MCR4 and MYOG, smaller for DECR1, HFABP4, and for CHX, and moderate for LEP genes. The heterozygosity average for all genes was higher in CPM (0.42±0.05) and similar in both the CC (0.33±0.06) and Yorkshire (0.35±0.05) breeds. In the estimation of genetic distances considering all genes, the CC breed are more distant from the Yorshire pigs.