These findings suggest a spectrum of partial 11β-HSD2 insufficiency in a Primary care cohort without the classical phenotype/genotype of AME. "Non-classical" AME may represent a phenotype of MR-activation and cardiovascular risk suggesting that these subjects could be targeted with MR antagonists.
Our results showed that average sodium intake was higher than recommended in both children and adults (WHO ≤2,000mg/d). The sodium intake estimated by dietary assessment correlated with urinary excretion in all subjects, but in obese adults was more inaccurate than in children. Future studies to validate the appropriate test to assess sodium intake by age and nutritional status are warranted.
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