STAT5 proteins are components of the common growth hormone and interleukin 2 family of cytokines' signaling pathway. Mutations in the STAT5b gene, described in 2 patients, lead to growth hormone insensitivity that resembles Laron syndrome. Clinical immunodeficiency was also present, although immunologic defects have not been well characterized thus far. Here we describe a 16-year-old girl who suffered generalized eczema and recurrent infections of the skin and respiratory tract since birth. She also suffered severe chronic lung disease and multiple episodes of herpetic keratitis. Clinical features of congenital growth hormone deficiency were observed, such as persistently low growth rate, severely delayed bone age, and postnatal growth failure resulting from growth hormone resistance. This combined phenotype of growth hormone insensitivity and immunodeficiency was attributable to a homozygous C-->T transition that resulted in a nonsense mutation at codon 152 in exon 5 of the STAT5b gene. This novel mutation determined a complete absence of protein expression. The main immunologic findings were moderate T-cell lymphopenia (1274/mm3), normal CD4/CD8 ratio, and very low numbers of natural killer (18/mm3) and gammadelta T (5/mm3) cells. T cells presented a chronically hyperactivated phenotype. In vitro T-cell proliferation and interleukin 2 signaling were impaired. CD4+ and CD25+ regulatory T cells were significantly diminished, and they probably contributed to the signs of homeostatic mechanism deregulation found in this patient. This new case, in accordance with 2 previously reported cases, definitely demonstrates the significant role of the STAT5b protein in mediating growth hormone actions. Furthermore, the main immunologic findings bring about an explanation for the clinical immunodeficiency features and reveal for the first time the relevant role of STAT5b as a key protein for T-cell functions in humans.
Os miúdos de frango, em especial a moela, apesar de pouco consumida pela população é uma ótima fonte protéica. Por isso o consumo rotineiro de moela fornece um ótimo suplemento nutricional, não possuindo custo elevado. Comparando-se o preço da moela com outras carnes mais consumidas, esta possui o menor valor por quilograma. Entre os benefícios do consumo da moela de frango estão um percentual de proteínas satisfatório, além de um baixo teor de lipídios totais. Podemos citar ainda, entre os nutrientes presentes na moela, vitaminas e minerais, sendo uma excelente fonte de ferro. Em relação à complementação alimentar, a moela pode ser utilizada em programas pró- desnutrição, por ser um alimento de baixo custo e alto valor nutricional. Para levantar dados sobre o consumo de moela, foi realizada uma pesquisa sobre o consumo de carnes, em um assentamento do MST (movimento dos Trabalhadores Rurais Sem Terra), na cidade de Ponta Porã, MS, e foram feitas análise da composição química e nutricional da moela cozida.
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