Acid Hydrolysis of 2' : 3'-isoPropyZidene Oa : 5'-cycloCytidine Toluene-p-sulphonate.-2' : 3'-bso-Propylidene 0 2 : 6'-cydocytidine toluene-p-sulphonate (24.6 mg.) was dissolved in water (1 c.c.) and sulphuric acid added (1 C.C. ; N.). The clear solution was heated on the steam-bath for 2 hours and ethanol (10 c.c.) added. The solution was evaporated to a small bulk (1 c.c.), and acetone (5 c.c.) added. When the mixture was kept at 0" overnight, colourless needle-like prisms separated (10.3 mg.). These were collected and washed with acetone: they had m. p. 218-219" (Kofler block), undepressed on admixture with an authentic specimen of cytidine sulphate.Paper chromatography (Whatman No. 1) of the hydrolysis product with tevL-butanoI-ammoniawater (80 : 4 : 18) confirmed its homogeneity and established the presence of sulphate ion and cytidine (RF = 0.25 ; reference cytidine spot, RF = 0.25).
The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.
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