Highlights d NGN2-BRN3A expression in human stem cells induces homogeneous sensory neurons (iSNs) d Three kinds of iSNs can be produced, including subtypes coexpressing TRPM8 and PIEZO2 d TRPM8 and PIEZO2 unexpectedly mark a subset of sensory neurons in humans, but not mice d iSNs from PIEZO2-deficient patients are insensitive to mechanical stimuli
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