SUMMARY
A Study of fifty‐six cases of polymorphic light eruption has shown that the action spectrum frequently lies in both the long ultraviolet wavelengths (320‐400 nm) and the short ultraviolet wavelengths below 320 nm.
Summary.— An investigation of photocontact dermatitis occurring in a dye manufacturing process is described. Sixteen employees were studied by photopatch testing to the complete anthraquinone‐based dye: Disperse Blue 35 and to chromatographically separated bands. By irradiation of the skin with visible light between 400 and 700 nm evidence was obtained to show that the complete dye produced photo‐contact dermatitis in individuals, whether they had previously been exposed to it or not. Using the same technique, only 4 of the 10 constituent hands produced a similar photocontact reaction.
Objective
Enhanced recovery protocols (ERPs) utilize multi-modal analgesia regimens. Individual regimen components should be evaluated for their analgesic efficacy. We evaluated the effect of scheduled intravenous (IV) acetaminophen within an ERP on analgesia and recovery after a major abdominal surgery.
Design
This study is a prospective, randomized, double-blinded clinical trial.
Setting
The study setting was a tertiary care, academic medical center.
Subjects
Adult patients scheduled for elective major abdominal surgical procedures
Methods
Patients in group A received 1g IV acetaminophen, while patients in group P received IV placebo every six hours for 48 hours postoperatively within an ERP. Pain scores, opioid requirements, nausea and vomiting, time to oral intake and mobilization, length of stay, and patient satisfaction scores were measured and compared.
Results
From 412 patients screened, 154 patients completed the study (Group A: 76, Group P: 78). Primary outcome was the number of patients with unsatisfactory pain relief, defined as a composite of average Numeric Rating Scale (NRS) scores above 5 and requirement of IV patient-controlled analgesia for pain relief during the first 48 hours postoperatively, and was not significantly different between the two groups (33 (43.4%) in group A versus 42 (53.8%) patients in group P, p=0.20). Opioid consumption was comparable between two groups. Group A utilized significantly less postoperative rescue antiemetics compared to group P (41% vs. 58%, p= 0.02).
Conclusions
Scheduled administration of IV acetaminophen did not improve postoperative analgesia or characteristics of postoperative recovery in patients undergoing major abdominal surgery within an ERP pathway.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.