Backgrounds and Aims: In developing countries, most infections can be prevented with relatively inexpensive infection prevention methods. However, there is limited information on standard precautions for infection prevention practices among health workers in Ethiopia Therefore, this study aimed to assess the compliance with the standard precaution of infection prevention practice and associated factors among health care workers (HCWs) using a mixed method study.Methods: A hospital-based mixed-methods study design (concurrent mixed method design) was conducted among 378 randomly selected health professionals. Selfadministered questionnaire; an in-depth interview and an observational checklist were used to collect the data. The collected data were cleaned and entered into Epi data and analyzed using a static package for social science. Descriptive statistics were conducted and the result was reported using frequency, and percentile.Logistic regression was performed to identify associated factors. Adjusted odds ratios with 95% confidence intervals (CIs) and p < 0.05 were used to explain statistically significant associations.
Results:The proportion of standard precaution practice among HCWs at Dessie specialized and comprehensive hospital was 55.6% (put the 95% CI). Age ≤ 25 years
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