The behavior of the low- and high-molecular weight glass formers confined in nanoporous templates remains an unsolved puzzle despite the intensive long-term studies in this matter. Special effort is taken to understand the enhancement of segmental or structural dynamics and the depression of the glass-transition temperatures, T gs in materials infiltrated in pores of the nanometric size. In this paper, we have analyzed dielectric, calorimetric, and contact angle data collected for various systems to determine which factors are responsible for these effects. It turned out that with increasing interfacial energy, molecules attached to the pore walls (interfacial layer) vitrify at higher temperatures. Moreover, the dynamics of core molecules starts to deviate from bulk-like behavior. Therefore, a greater depression of the glass-transition temperature, T g, of this fraction of molecules is noted. Also, it was found that the sensitivity of structural dynamics to the density fluctuations, quantified by the pressure coefficient of the glass-transition temperature, dT g/dp, is another useful parameter to predict the shift of the glass-transition temperature of the confined glass formers. The results presented herein emphasize the great importance of surface effects, which play a primary role in a unified description of the impact of the nanometric spatial restriction on the dynamics of confined materials.

The obtained results for COLO829 melanoma cells were compared with data for normal dark pigmented melanocytes and the use of ciprofloxacin as a potential anticancer drug for the treatment of melanoma in vivo was considered.

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