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Artigo/Article Reações adversas em pacientes com doença de Chagas tratados com benzonidazol, no Estado do Ceará ABSTRACTIntroduction: Chagas disease is caused by Trypanosoma cruzi and treated with benznidazole (BNZ). This drug has the troublesome features of presenting partial effectiveness and high toxicity ranging from hypersensitivity reactions to medullary aplasia. The objective here was to describe and evaluate the occurrence of adverse reactions in Chagas disease patients treated with benznidazole in Fortaleza, Ceará. Methods: This was a prospective descriptive study involving 32 chronic Chagas patients treated with benznidazole between January 2005 and April 2006. Sociodemographic and clinical data were collected through questionnaires, interviews and laboratory tests. Blood samples were collected before treatment and after 30 and 60 days of treatment. Results: Adverse reactions were reported in 28 patients (87.5%) patients and the most frequent of these were pruritus (50%), prickling (43.8%), muscle weakness (37.5%) and skin rash (31.3%). Out of the 28 patients with adverse reactions, eight (28.57%) discontinued their treatment. The adverse reactions that culminated with discontinuation of the treatment were prickling (7; 87.5%) or skin eruptions (5; 62.5%). There was a slight increase in aminotransferase levels during the treatment in 9.4% of the patients. Conclusions: Following up the drug therapy administered to Chagas patients is of great importance for prevention and early detection of adverse reactions to drugs.

Introduction Adverse drug reactions (ADRs) to antiinfectives affect especially hospitalized children and contribute to increased morbidity, mortality, length of stay, and costs in healthcare systems. Objective To assess ADRs associated with antiinfectives use in Brazilian hospitalized children. Methods A prospective cohort study was conducted in five public hospitals over six months. Children aged 0 to 11 years and 11 months who were hospitalized for more than 48 hours and prescribed antiinfectives for over 24 hours were included. Results A total of 1.020 patients met the inclusion criteria. Of these, 152 patients experienced 183 suspected ADRs. Most reactions were related to the gastrointestinal system (65.6%), followed by skin reactions (18.6%). Most reactions were classified as probable causality (58.5%), moderate severity (61.1%), and unavoidable (56.2%). Our findings showed that ADRs were associated with increased length of stay (p < 0.001), increased length of therapy (p <0.015), increased days of therapy (p = 0.038), and increased number of antiinfectives prescribed per patient (p < 0.001). Conclusion Almost 15% of hospitalized children exposed to antiinfectives presented suspected ADRs. Their occurrence was classified as probable, of moderate severity, and unavoidable. ADRs were significantly influenced by the length of hospital stay and the number of antiinfectives prescribed per patient.

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INTRODUÇÃO: O tumor sólido pseudopapilar do pâncreas, descrito pela primeira vez por Frantz em 1959, corresponde a uma neoplasia rara dos tumores pancreáticos de origem não endócrina. OBJETIVO: Discutir um caso atípico de neoplasia abdominal, com diagnóstico de tumor sólido pseudopapilar do pâncreas. DISCUSSÃO DE CASO: E.C.M.A., 19 anos, sexo feminino, queixando-se de dor epigástrica há 7 meses, associada a náuseas e vômitos frequentes. A ultrassonografia revelou a presença de uma massa sólida em região epigástrica, corroborando com a tomografia computadorizada, onde se evidenciou uma volumosa lesão expansiva epigástrica, predominantemente hipodensa, de limites bem definidos. Foi submetida à laparotomia com pancreatectomia de corpo e cauda. Apresentou boa evolução no pós-operatório, obtendo alta no 5º dia. CONSIDERAÇÕES FINAIS: A ressecção completa oferece aos pacientes bom prognóstico, com taxas de sobrevida de 90%.