Figure 1. Magnetic resonance imaging of the elbow in a 78-year-old patient with ulnar neural leprosy. Images of the left arm before contrast administration: (a) axial TSE-T1w; (b) axial TSE-T2w; (c) coronal TSE-T1w. Images of the left arm obtained after contrast administration: TSE-T1w FS on (d) axial plane, and (e) coronal plane. (TSE, turbo spin echo; T1w, T1-weighted; T2w, T2-weighted; FS, with fat suppression.).
The combination of antiviral and anti-inflammatory properties of Clofaximine as experienced in clinical practice, could lead to take into consideration its effects in COVID 19Clofazimine is a rimophenazine dye originally used as an antitubercolar agent after its first synthesis at Trinity College of Dublin, during 1954, by a group of scientist led by V. Barry. Only few years later it was awarded for leprosy treatment by Y. T. Chang. With the following years, also an anti-inflammatory effectiveness on erythema nodosum leprosum was recognized (1 ). In the '70s therapeutical activity on discoid lupus erythematosus and pyoderma gangrenosum were documented ( 2 ).Recent papers suggest interesting properties of modulation of the immune responses: first by blockade of Kv 1.3 potassium channel, a voltage dependent transmembrane domain first identified outside electrically excitable tissue, for instance on macrophages and T lymphocytes; in the latters it carries on a critical role for the subset of "effector memory" ( CD4+ CD62L lo CD44hi) when blocked, downgrading such function in severe, inflammatory diseases, and expanding, instead, "central memory" population, ( CD4+ CD 62Lhi CD44hi), ( 3,4 ).
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