Setting: Directly Observed Treatment Short-course is a key pillar of the global strategy to end tuberculosis. Objective: The effectiveness of community-based compared to facility-based DOTS on tuberculosis treatment success rates in Namibia was assessed. Methods: Annual tuberculosis treatment success, cure, completion and case notification rates were compared between 1996 and 2015 by interrupted time series analysis. The intervention was the upgrading by the Namibian government of the tuberculosis treatment strategy from facility-based to community-based DOTS in 2005.Results: The mean annual treatment success rate during the pre-intervention period was 58.9% (range: 46-66%) and significantly increased to 81.3% (range: 69-87%) during the post-intervention period. Before the intervention there was a non-significant increase (0.3%/year) in the annual treatment success rate. After the intervention, the annual treatment success rate increased abruptly by 12.9% (p <0.001) and continued to increase by 1.1%/year thereafter. The treatment success rate seemed to have stagnated at approximately 85% at the end of the observation period. Conclusion:Expanding facility-based DOTS to community-based DOTS significantly increased the annual treatment success rates. However, the treatment success rate at the end of the observation period had stagnated below the targeted 95% success rate.
BackgroundHypertension has been identified as the single greatest contributor to the global burden of disease and mortality, with estimates suggesting that the highest levels of blood pressure have shifted from high-income countries to low-income countries in sub-Saharan Africa. While evidence suggests a remarkably high prevalence of hypertension among urban residents in Namibia, national estimates to inform on the country-level burden are lacking. This study estimates the prevalence and predictors of hypertension among Namibian adults.MethodsThe analysis is based on 1,795 women and 1,273 men aged 35–64 years from the nationally-representative 2013 Namibia Demographic and Health Survey. Odds radios and 95% confidence intervals were estimated using logistic regression.ResultsThe age-standardized prevalence of hypertension was 46.0% (men vs. women: 46.1% vs. 46.0%). Mean systolic and diastolic blood pressures for the total population were 128.8 mmHg (95% CI 127.8–129.7) and 83.1 mmHg (95% CI 82.5–83.7), respectively. Mean systolic blood pressure was significantly lower among women (men vs. women: 130.9 mmHg vs. 127.4 mmHg; p<0.001). There were no statistically significant differences in mean diastolic blood pressure between men and women. Older age, urban residence, and being either overweight or obese were positively associated with the odds of hypertension (p<0.01). For women, the odds of hypertension were also significantly increased for those who were diabetic (i.e. had a fasting blood glucose level greater than 7.0 mmol/L) and reduced for those with higher levels of education.ConclusionThe prevalence of hypertension among Namibian adults is high and associated with metabolic and socio-demographic factors. Future research examining disease comorbidity and behavioral risk factors could better inform on the disease burden and help target resources to optimize prevention and control.
The study identified access barriers to ART for HIV-positive TB patients and their relevance in Namibia. The findings provide evidence for tailored interventions to increase ART-uptake among HIV-positive TB patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.