Fingers on the pulse: An NMR pulse scheme that provides full sensitivity in homodecoupled band‐selective NMR spectroscopy experiments is proposed (see figure). The easy implementation of this HOBS scheme as a general building block into a great variety of multidimensional NMR experiments leads to pure‐shift spectra with enhanced resolution and with the maximum attainable sensitivity.

A general NMR approach to provide pure in-phase (PIP) multiplets in heteronuclear correlation experiments is described. The implementation of a zero-quantum filter efficiently suppresses any unwanted anti-phase contributions that usually distort the multiplet pattern of cross-peaks and can hamper their analysis. The clean pattern obtained in PIP-HSQMBC experiments is suitable for a direct extraction of coupling constants in resolved signals, for a peak-fitting process from a reference signal, and for the application of the IPAP technique in non-resolved multiplets.

NMR enantiodifferentiation studies are greatly improved by the simultaneous determination of (1)H and (13)C chemical shift differences through the analysis of highly resolved cross-peaks in spectral aliased pure shift (SAPS) HSQC spectra.

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Improved sensitivity: A novel strategy to enhance the experimental sensitivity in spatially encoded NMR experiments has been developed. The use of a multiple-frequency modulated pulse applied simultaneously to an encoding gradient can afford a substantial sensitivity gain with respect to single-slice selected experiments.