A practical CuI/(R)-Fesulphos catalyzed 1,3-dipolar cycloaddition of azomethine ylides with azirines has been developed to produce highly valuable enantioenriched diazabicyclo[3.1.0]hexanes.
A three-step reaction sequence has been developed to prepare a variety of enantioenriched pyrroloisoquinoline derivatives. The process involves a catalytic asymmetric azomethine ylide 1,3-dipolar cycloaddition followed by an intramolecular Au-catalyzed alkyne hydroamination and enamine reduction.
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