The release of modified mosquitoes to suppress/replace vectors constitutes a promising tool for vector control and disease prevention. Evidence regarding these innovative modification techniques is scarce and disperse. This work conducted a systematic review, gathering and analysing research articles from PubMed and Biblioteca Virtual em Saúde databases whose results report efficacy and non-target effects of using modified insects for disease prevention, until 2016. More than 1500 publications were screened and 349 were analysed. Only 12/3.4% articles reported field-based evidence and 41/11.7% covered modification strategies' post-release efficacy. Variability in the effective results (90/25.7%) questioned its reproducibility in different settings. We also found publications reporting reversal outcomes 38/10.9%, (e.g. post-release increase of vector population). Ecological effects were also reported, such as horizontal transfer events (54/15.5%), and worsening pathogenesis induced by natural wolbachia (10/2.9%). Present work revealed promising outcomes of modifying strategies. However, it also revealed a need for field-based evidence mainly regarding epidemiologic and long-term impact. It pointed out some eventual irreversible and important effects that must not be ignored when considering open-field releases, and that may constitute constraints to generate the missing field evidence. Present work constitutes a baseline of knowledge, offering also a methodological approach that may facilitate future updates.

IntroductionIn late 2019, an epidemic outbreak emerges in China caused by a new coronavirus with high transmission and human infection potential which in March 2020, was characterized by WHO as a pandemic. The lockdown has repercussions on the population’s well-being, reflected in their food choices. There is a tendency to increase the consumption of energy dense food, rich in fat and carbohydrates, which are related to an increased risk of depression.ObjectivesThe main goal of this non-systematic literature review was to understand the impact of the Mediterranean Diet on Mental Health promotion in SARSCoV-2 pandemic.MethodsLiterature from Pubmed database were searched, with the following keywords: COVID-19, Depression, Anxiety, Mental Health and Mediterranean Diet.ResultsStudies indicate that a diet based on the Mediterranean Diet is associated with a decreased risk of developing depressive symptoms, especially when there is moderate to high adherence to this dietary pattern. High consumption of plant and fish foods, reduced consumption of sugary products, processed and red meats and the use of olive oil as a fat source, are principles of the Mediterranean diet, associated with an improvement in endothelial function, increased levels of eicosanoids and serotonin synthesis and regulation of serotonin which seem to explain this protective effect.ConclusionsIn addition to decreasing the risk of obesity, diabetes, and hypertension, comorbidities associated with the most serious disease of COVID-19, the Mediterranean Diet seems to play an important role in promoting mental health, with a decreased risk of developing depressive symptoms.DisclosureNo significant relationships.

Hysterectomy is the most frequent surgical procedure in gynecology, and it can be performed using several surgical techniques and for various clinical indications. The aim of this poster is to understand in what way the removal of the uterus conditions anatomical, physiological and psychological changes in the woman, and in what way these changes influence her sexuality.

2The modification and release of insects to suppress or replace natural insect vectors constitutes 3 a promising tool for vector control and disease prevention, facing the unprecedented global 4 emergence of vector-borne diseases. Little is known regarding these innovative modification 5 strategies and available evidence is not standardized turning it difficult to reflect on their actual 6 efficacy and eventual effects. 7This work conducted a systematic review, gathering and analyzing research articles from PubMed 8 and Biblioteca Virtual em Saúde databases whose results directly report efficacy and effects of 9 the use of modified insects for disease prevention until 2016. Within more than 1500 publications 10 that were screened a total of 349 where analyzed. 11A total of 12/3.4% reported field-based evidence, and 41/11.7% covered modification stretagies' 12 efficacy after insects' release, their epidemiology impact or its long-term efficacy. Examples of 13 successful results were the replacement of natural field populations by wolbachia-infected 14 mosquitoes in 5 weeks, and the elimination of a population in laboratory cages after transgenic 15 mosquitoes release over 10-20 weeks. Variability in the effective results were described 16 (90/25.7%) questioning its reproducibility in different settings. We also found 38/10.9% 17 publications reporting reversal outcomes, such as an increase of vector population after release. 18Ecological effects such as horizontal transfer events to non-target species (54/15.5%), and 19 wolbachia-induced worsening pathogenesis on mammal filarial diseases (10/2.9%) were also 20 reported. 21Present work revealed promising outcomes of both suppressing and replacing approaches. 22However, it also revealed a need of field-based evidence mainly regarding epidemiologic and 23 long-term impact of insect modification strategies. It pointed out some eventual irreversible and 24 important effects that must not be ignored when considering open-field releases, and that may 25 constitute constraints to generate the missing field evidence. Moreover, the level of variability of 26 existing evidence suggests the need of local/specific evidence in each setting of an eventual 27 release. 28 29 30 31 32 33 34 35