It is widely reported that a picture of an angry face seems to figuratively pop out of an array of happy faces, although all of these reports are based on a single experiment by Hansen and Hansen. Pop out, when it occurs, indicates that an observer has located the target by means of a preattentive, parallel search. Hansen and Hansen concluded that it was the affect displayed by the face which caused it to pop out from its surrounding distracters. However, Hansen and Hansen's angry faces contained extraneous dark areas which were introduced when they transformed Ekman and Friesen's photographs of angry and happy faces into black-on-white sketches. When the original artifact-free gray-scaled versions of angry and happy faces were used no evidence for pop out was found. All target faces were found during a serial, self-terminating search regardless of their expression. The angry face in Hansen and Hansen's experiments may have popped out from a crowd of happy faces because of a contrast artifact inadvertently introduced when they created their stimuli.

Trastuzumab is an effective treatment for patients with metastatic breast cancer (MBC) that overexpresses HER-2. A high incidence of brain metastases (BM) has been noted in patients receiving trastuzumab. A retrospective chart review was conducted of 100 patients commencing trastuzumab for metastatic breast cancer from July 1999 to December 2002, at the Christie Hospital. Seven patients were excluded; five patients developed central nervous system metastases prior to starting trastuzumab, and inadequate data were available for two. Out of the remaining 93 patients, 23 (25%) have developed BM to date. In all, 46 patients have died, and of these 18 (39%) have been diagnosed with BM prior to death. Of the 23 patients developing BM, 18 (78%) were hormone receptor negative and 18 (78%) had visceral disease. Univariate analysis showed a significant association between the development of cerebral disease and both hormone receptor status and the presence of visceral disease. In conclusion, a high proportion of patients with MBC treated with trastuzumab develop symptomatic cerebral metastases. HER-2-positive breast cancer may have a predilection for the brain, or trastuzumab therapy may change the disease pattern by prolonging survival. New strategies to address this problem require investigation in this group of patients.

No abstract

Goserelin offers an effective, well-tolerated alternative to CMF in premenopausal patients with ER-positive and node-positive early breast cancer.

PURPOSE Previous studies of hypofractionated adjuvant whole-breast radiotherapy for early breast cancer established a 15- or 16-fraction (fr) regimen as standard. The FAST Trial (CRUKE/04/015) evaluated normal tissue effects (NTE) and disease outcomes after 5-fr regimens. Ten-year results are presented. METHODS Women ≥ 50 years of age with low-risk invasive breast carcinoma (pT1-2 pN0) were randomly assigned to 50 Gy/25 fr (5 weeks) or 30 or 28.5 Gy in 5 fr of 6.0 or 5.7 Gy (1 week). The primary end point was change in photographic breast appearance at 2 and 5 years; secondary end points were physician assessments of NTE and local tumor control. Odds ratios (ORs) from longitudinal analyses compared regimens. RESULTS A total of 915 women were recruited from 18 UK centers (2004-2007). Five-year photographs were available for 615/862 (71%) eligible patients. ORs for change in photographic breast appearance were 1.64 (95% CI, 1.08 to 2.49; P = .019) for 30 Gy and 1.10 (95% CI, 0.70 to 1.71; P = .686) for 28.5 Gy versus 50 Gy. α/β estimate for photographic end point was 2.7 Gy (95% CI, 1.5 to 3.9 Gy), giving a 5-fr schedule of 28 Gy (95% CI, 26 to 30 Gy) estimated to be isoeffective with 50 Gy/25 fr. ORs for any moderate/marked physician-assessed breast NTE (shrinkage, induration, telangiectasia, edema) were 2.12 (95% CI, 1.55 to 2.89; P < .001) for 30 Gy and 1.22 (95% CI, 0.87 to 1.72; P = .248) for 28.5 Gy versus 50 Gy. With 9.9 years median follow-up, 11 ipsilateral breast cancer events (50 Gy: 3; 30 Gy: 4; 28.5 Gy: 4) and 96 deaths (50 Gy: 30; 30 Gy: 33; 28.5 Gy: 33) have occurred. CONCLUSION At 10 years, there was no significant difference in NTE rates after 28.5 Gy/5 fr compared with 50 Gy/25 fr, but NTE were higher after 30 Gy/5 fr. Results confirm the published 3-year findings that a once-weekly 5-fr schedule of whole-breast radiotherapy can be identified that appears to be radiobiologically comparable for NTE to a conventionally fractionated regimen.

No abstract

We have found that a picture of a face is more easily detected than is a pattern of arbitrarily rearranged facial features. An upright face is also more detectable than an inverted face. Using two-alternative forced-choice visual masking paradigms, we have found that this face-detection effect (FDE) can be produced with line drawings and with photocopies of a picture of a face. Our results suggest that a face, as an organized, meaningful pattern, is a more potent stimulus than an arbitrary assemblage of the same visual features. It may be that the FDE is a visual configuration effect. Previous visual configuration effects have been documented only with recognition responses. The FDE, by contrast, documents a configuration effect that affects the detectability of a stimulus.

In a recent study, McCauley, Parmelee, Sperber, and Carr (1980) reported results indicating that semantic priming had been produced by visual stimuli that were backward masked at durations too brief for greater than chance report. The conclusions drawn from such an experiment are critically dependent upon whether or not the primes were actually masked below the threshold for identification during priming trials. The three experiments reported here provide evidence that this requirement was not met. Rather, McCauley et al.'s (1980) methodology allowed for an uncontrolled increase in light adaptation during the actual testing of prime efficacy in the priming session. This increase in light adaptation reduced the effectiveness of the backward mask and resulted in an increase in prime visibility during priming trials. Thus, semantic priming probably occurred under conditions in which commensurate visual information was actually available.