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Patients presenting for gastrointestinal endoscopy at a group of public university-affiliated hospitals where most sedation is managed by anaesthetists, had a high risk profile and a substantial incidence of significant unplanned intraoperative events and 30-day mortality.

Population stereotypes for color were tested using a paper-and-pencil test. Seven hundred and eighty-four Yunnan Province Chinese subjects of both sexes from a wide range of ages and backgrounds were asked to indicate color associations for nine concepts such as go, off, and stop, using eight colors. The results indicated that the Chinese subjects did not yield such clearcut associations as those found with U.S. subjects. Red for stop and green for go, which have virtually perfect association for American subjects, were not particularly strong associations for the Chinese subjects. Also, the Chinese chose green for "on," whereas U.S. subjects were more likely to choose red.

The activity of the pro-inflammatory cytokine IL (interleukin)-1 is closely regulated in vivo via a variety of mechanisms, including both the control of IL-1 production and secretion as well as naturally occurring inhibitors of IL-1 function, such as IL-1ra (IL-1 receptor antagonist). IL-1ra is homologous with IL-1, and is able to bind but not activate the IL-1 receptor. IL-1ra can be produced by a variety of cell types, and its production is stimulated by inflammatory signals. In the present study, we show that in macrophages the TLR (Toll-like receptor)-mediated induction of IL-1ra from both its proximal and distal promoters involves the p38 and ERK1/2 (extracellular-signal-regulated kinase 1/2) MAPK (mitogen-activated protein kinase) cascades. In addition, we show that MSK1 and 2 (mitogen- and stress-activated kinase 1 and 2), kinases activated by either ERK1/2 or p38 in vivo, are required for the induction of both IL-1ra mRNA and protein. MSKs regulate IL-1ra transcription via both IL-10-dependent and -independent mechanisms in cells. Consistent with this, knockout of MSK in mice was found to result in a decrease in IL-1ra production following LPS (lipopolysaccharide) injection. MSKs therefore act as important negative regulators of inflammation following TLR activation.

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This experiment investigated the effects of foveal cognitive load on a primary peripheral single-target detection task. Four levels of foveal task with cognitive loads involving identification and summation of numerals were used. Number of correct targets detected seemed unaffected by the foveal load in the near periphery but a decrement occurred beyond 7.7 degrees. Response times for correct responses showed large dispersion compared with that for correct locations. At a low cognitive load, foveal task performance showed no deterioration for all eccentricities tested, but at a higher cognitive load performance declined gradually across eccentricities. Mild evidence of tunnel vision was obtained as indicated by the significant interaction of cognitive loads x eccentricities. Resources theory accounted well for the results.

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